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NCT01173354 · ClinicalTrials.gov registry record · NA
EAA Intake to Optimize Protein Anabolism in COPD
A NA study, sponsored by Texas A&M University.
- Completed
- Registry status
- NA
- Development phase
- 34
- Enrollment target
NCT01173354 is a NA study that has completed, run by Texas A&M University. The registered enrollment target is 34 participants.
The verdict
NCT01173354, a NA study, has completed, sponsored by Texas A&M University.
- COMPLETED
- Registry status
- NA
- Development phase
- 34 participants
- Enrollment target
Study Summary
Weight loss commonly occurs in patients with chronic obstructive pulmonary disease (COPD), negatively influencing their quality of life, treatment response and survival. Loss of muscle protein is generally a central component of weight loss in COPD patients. Attempts to reverse muscle loss in COPD by supplying large amounts of protein or calories to these patients have been unsuccessful. Gains in muscle mass are difficult to achieve in COPD unless specific metabolic abnormalities are targeted. The investigators recently observed that alterations in protein metabolism are present in normal weight COPD patients. Elevated levels of protein synthesis and breakdown rates were found in this COPD group indicating that alterations are already present before muscle wasting occurs. Furthermore, reduced plasma essential amino acid (EAA) levels were observed in COPD patients. These reduced EAA plasma levels were significantly related with the presence of muscle wasting in COPD. Until now, limited research has been done examining protein metabolism and the response to feeding in patients with COPD. Previous studies support the concept of essential amino acids (EAA) as an anabolic stimulus in the young and elderly and in insulin resistant states. Until yet no information is present on the anabolic effects of EAA in elderly COPD patients. It is therefore our hypothesis that a high-leucine essential amino acids mixture specifically designed to stimulate protein anabolism will target the metabolic alterations of COPD patients. In the present study, the acute effects of an EAA nutritional supplement on whole body, muscle and liver protein metabolism will be examined in COPD patients and compared to a supplement consisting of a balanced mixture of total amino acids. The principal endpoints will be the extent of stimulation of whole body protein synthesis as this is the principal mechanism by which either amino acid or protein intake causes muscle anabolism, and the reduction in endog
Interventions
- DIETARY_SUPPLEMENT Free balanced amino acid mixture
- DIETARY_SUPPLEMENT Free essential amino acid mixture
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2009-09-08 |
| Est. Completion | 2012-02-17 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01173354
The ClinicalTrials.gov registry entry for NCT01173354 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 34 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Texas A&M University, which has 95 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Free balanced amino acid mixture is the first listed.
NCT01173354 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01173354 about?
NCT01173354 is a clinical study titled "EAA Intake to Optimize Protein Anabolism in COPD". Weight loss commonly occurs in patients with chronic obstructive pulmonary disease (COPD), negatively influencing their quality of life, treatment response and survival. Loss of muscle protein is generally a central component of weight loss in COPD patients. Attempts to reverse muscle loss in COPD b...
What is the current status of trial NCT01173354?
This trial is currently completed. It is a NA study. The enrollment target is 34 participants. The study started on 2009-09-08. Estimated completion is 2012-02-17.
What interventions are being tested in trial NCT01173354?
The interventions under investigation include: Free balanced amino acid mixture (DIETARY_SUPPLEMENT), Free essential amino acid mixture (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT01173354?
This trial is sponsored by Texas A&M University, which has 95 total clinical trials registered on ClinicalTrials.gov.
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