Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01143844 · ClinicalTrials.gov registry record
Assessing Fertility Potential in Female Cancer Survivors
A clinical trial of Effects of Chemotherapy, sponsored by University of Pennsylvania.
- Completed
- Registry status
- 391
- Enrollment target
- 2
- Study locations
NCT01143844: Completed study of Effects of Chemotherapy, sponsored by University of Pennsylvania.
NCT01143844 is a study of Effects of Chemotherapy that has completed, run by University of Pennsylvania. The registered enrollment target is 391 participants. The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01143844, a study of Effects of Chemotherapy, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- 391 participants
- Enrollment target
- 2
- Study locations
Study Summary
Hypothesis: Girls and women exposed to chemotherapy and/or radiation therapy experience endocrine changes more similar to women in their late reproductive years than to same-age peers. These changes will be more dramatic in women who receive high dose therapy compared to women who receive low dose therapy. At annual visits over 3-5 years, a combination of physical exam, medical history, menstrual diary keeping, pelvic ultrasound and blood hormones tests will be used to measure "ovarian reserve" , that is the number and quality of the eggs that remain in the ovaries. The study will also try to learn if those who received higher doses of certain chemotherapies are more likely to have changes in these tests sooner than those women who received smaller doses of these same drugs. Additionally a DNA (deoxyribonucleic acid) sample will be collected to look for gene variations that may predict susceptibility to ovarian damage from cancer treatments. Information learned from this study may help researchers to develop guidelines to identify problems with a female cancer survivor's ovaries before irregular menses or other symptoms of ovarian failure occur.
Primary Outcome
Primary Outcomes for this study will include mean and changes in reproductive hormone measures obtained during the early follicular phase of the menstrual cycle (days 1-4).
Conditions Studied
Study Locations (2)
Pennsylvania
- Penn Reproductive Research Unit, 3701 Market Street, Suite 810 - Philadelphia
- Penn Medicine at Radnor, 250 King of Prussia Road - Radnor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 391 participants |
| Start Date | 2006-03 |
| Est. Completion | 2020-03-30 |
What the finished NCT01143844 record still lists
NCT01143844 is an observational study that tracks outcomes without assigning an intervention. The registered 391 participants enrollment target is mid-sized for trials with a published cap.
The record links to 1 condition, with Effects of Chemotherapy appearing as the primary indexed condition, and to 0 interventions.
NCT01143844 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT01143844 about?
NCT01143844 is a clinical study titled "Assessing Fertility Potential in Female Cancer Survivors". Hypothesis: Girls and women exposed to chemotherapy and/or radiation therapy experience endocrine changes more similar to women in their late reproductive years than to same-age peers. These changes will be more dramatic in women who receive high dose therapy compared to women who receive low dose t...
What is the current status of trial NCT01143844?
This trial is currently completed. The enrollment target is 391 participants. The study started on 2006-03. Estimated completion is 2020-03-30.
What conditions does trial NCT01143844 study?
This clinical trial studies the following conditions: Effects of Chemotherapy.
Who is sponsoring clinical trial NCT01143844?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01143844 being conducted?
This trial has 2 study locations across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Effects of Chemotherapy
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT06397703 · 392 participants · Phase 2
ADT and SBRT vs SBRT Alone for Unfavorable Intermediate Risk Prostate Cancer
- NCT06625775 · 392 participants · Phase 1
Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
- NCT07220967 · 392 participants · Phase 4
A Study of Antibiotic Delivery to Prevent Infection After Breast Tissue Expander Placement
- NCT07290036 · 392 participants · Phase 1
A Study to Learn if Bimekizumab Given in Different Ways is Safe and Moves Similarly Throughout the Body Over Time in Adults
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia