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NCT01132573 · ClinicalTrials.gov registry record · Phase 1
Entinostat and Clofarabine in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Poor-Risk Acute Lymphoblastic Leukemia or Bilineage/Biphenotypic Leukemia
A Phase 1 study of Recurrent Adult Acute Lymphoblastic Leukemia and Untreated Adult Acute Lymphoblastic Leukemia, sponsored by National Cancer Institute (NCI).
- Completed
- Registry status
- Phase 1
- Development phase
- 27
- Enrollment target
- 4
- Study locations
NCT01132573 is a Phase 1 study of Recurrent Adult Acute Lymphoblastic Leukemia and Untreated Adult Acute Lymphoblastic Leukemia that has completed, run by National Cancer Institute (NCI). The registered enrollment target is 27 participants, below the 67-participant average among 8 other Recurrent Adult Acute Lymphoblastic Leukemia trials with a reported enrollment target (60% lower). The trial reports 4 study locations across 2 states.
The verdict
NCT01132573, a Phase 1 study of Recurrent Adult Acute Lymphoblastic Leukemia and Untreated Adult Acute Lymphoblastic Leukemia, has completed, sponsored by National Cancer Institute (NCI).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 27 participants
- Enrollment target
- 4
- Study locations
Study Summary
This phase I trial studies the side effects and best dose of entinostat when given together with clofarabine in treating patients with newly diagnosed, relapsed, or refractory poor-risk acute lymphoblastic leukemia or bilineage/biphenotypic leukemia. Entinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as clofarabine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving entinostat with clofarabine may kill more cancer cells.
Conditions Studied
Interventions
- OTHER laboratory biomarker analysis
- OTHER pharmacological study
- DRUG clofarabine
- DRUG entinostat
Study Locations (4)
Colorado
- University of Colorado Anschutz Medical Campus - Aurora
- University of Colorado - Denver
Maryland
- University of Maryland/Greenebaum Cancer Center - Baltimore
- Johns Hopkins University/Sidney Kimmel Comprehensive Cancer Center - Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2010-04 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01132573
The ClinicalTrials.gov registry entry for NCT01132573 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 27 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 67-participant average among 8 other Recurrent Adult Acute Lymphoblastic Leukemia trials with a reported enrollment target (60% lower). The listed sponsor is National Cancer Institute (NCI), which has 3,257 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Recurrent Adult Acute Lymphoblastic Leukemia appearing as the primary indexed condition, and to 4 interventions - of which laboratory biomarker analysis is the first listed.
NCT01132573 reports 4 study locations spanning 2 distinct geographic areas - top geographies include Colorado, Maryland.
Frequently Asked Questions
What is clinical trial NCT01132573 about?
NCT01132573 is a clinical study titled "Entinostat and Clofarabine in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Poor-Risk Acute Lymphoblastic Leukemia or Bilineage/Biphenotypic Leukemia". This phase I trial studies the side effects and best dose of entinostat when given together with clofarabine in treating patients with newly diagnosed, relapsed, or refractory poor-risk acute lymphoblastic leukemia or bilineage/biphenotypic leukemia. Entinostat may stop the growth of cancer cells by...
What is the current status of trial NCT01132573?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 27 participants. The study started on 2010-04.
What conditions does trial NCT01132573 study?
This clinical trial studies the following conditions: Recurrent Adult Acute Lymphoblastic Leukemia, Untreated Adult Acute Lymphoblastic Leukemia, Acute Leukemias of Ambiguous Lineage, Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia.
What interventions are being tested in trial NCT01132573?
The interventions under investigation include: laboratory biomarker analysis (OTHER), pharmacological study (OTHER), clofarabine (DRUG), entinostat (DRUG).
Who is sponsoring clinical trial NCT01132573?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01132573 being conducted?
This trial has 4 study locations across Colorado, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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