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NCT01106209 · ClinicalTrials.gov registry record
Neutrophil Extracellular Trap Formation in Newborn Infants at Risk for Inflammatory Syndromes
A clinical trial, sponsored by University of Utah.
- Terminated
- Registry status
- 14
- Enrollment target
NCT01106209: Clinical Trial study, sponsored by University of Utah.
NCT01106209 is a clinical trial that was terminated before completion, run by University of Utah. The registered enrollment target is 14 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01106209 was terminated before completion, sponsored by University of Utah.
- TERMINATED
- Registry status
- 14 participants
- Enrollment target
Study Summary
The purpose of this study is to characterize the time to maturation of neutrophil extracellular trap(NET) formation capability in polymorphonuclear leukocytes(PMNs) isolated from newborn premature and term infants. Preterm infants who are enrolled into the study who then go on to require surgery \<1 year due to surgical NEC, will have the NET formation reassessed. This study will also determine whether NETs contribute to the pathogenesis of necrotizing enterocolitis (NEC). We hypothesize that NET formation contributes to the pathogenesis of NEC by inappropriately releasing degradative proteins and tissue destructive enzymes into the inflammatory milieu of the premature infant gastrointestinal tract following bacterial translocation. We also hypothesize that the delay in NEC development in premature infants (3rd - 4th week of life) as compared to at-risk term infants (1st week of life) results from a developmental delay in PMN ability to form NETs.
Primary Outcome
The objective is to characterize the time to maturation of NET formation capability in polymorphonuclear leukocytes(PMNs)isolated from newborn infants.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2010-04 |
| Est. Completion | 2020-06-22 |
Why NCT01106209 stopped before completion
NCT01106209 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 14 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01106209 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01106209 about?
NCT01106209 is a clinical study titled "Neutrophil Extracellular Trap Formation in Newborn Infants at Risk for Inflammatory Syndromes". The purpose of this study is to characterize the time to maturation of neutrophil extracellular trap(NET) formation capability in polymorphonuclear leukocytes(PMNs) isolated from newborn premature and term infants. Preterm infants who are enrolled into the study who then go on to require surgery \<1...
What is the current status of trial NCT01106209?
This trial is currently terminated. The enrollment target is 14 participants. The study started on 2010-04. Estimated completion is 2020-06-22.
Who is sponsoring clinical trial NCT01106209?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
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