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NCT00884702 · ClinicalTrials.gov registry record
Regional Rates of Cerebral Protein Synthesis: Effects of Sleep and Memory Consolidation
A clinical trial, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 538
- Enrollment target
NCT00884702: Completed study, sponsored by National Institute of Mental Health (NIMH).
NCT00884702 is a clinical trial that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 538 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00884702 has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 538 participants
- Enrollment target
Study Summary
Background: * The brain needs sleep to function normally, but the purpose of sleep is not understood. Brain activity decreases during sleep, so it may be that sleep is important to maintain, repair, or reorganize brain cells. In animals, the formation of brain proteins increases during sleep, and the same thing may happen in humans. * There is also evidence that learning and memory are helped by sleep, and that the synthesis of proteins in the brain are involved. Objectives: * To examine the formation of proteins in the brain while people are awake, deprived of sleep, and during sleep. * To look at the formation of proteins in the brain while awake or asleep and following learning a task. Eligibility: * Healthy volunteers between 18 and 28 years of age. * Volunteers must not have psychiatric, neurologic, or sleep disorders or certain types of vision problems, and must be able to undergo imaging studies. Design: * Study Part I (protein formation in waking, sleep deprivation, and sleep): * Participants will wear an actigraph (a unit to record motor activity) for 2 weeks prior to admission. * Participants will have physical and psychological examinations, along with a blood sample. * After admission participants will have three positron emission tomography (PET) scans to study protein formation and one magnetic resonance imaging (MRI) scan over the course of two days. * Participants may be asked to stay awake for as long as 20 hours and will be monitored throughout. * Participants will be able to sleep overnight after they complete the required scans and monitoring, and will be discharged the following morning. * Study Part II (protein formation in waking and sleep combined with a learning task): * Participants will wear an actigraph (a unit to record motor activity) for 2 weeks prior to admission. * Participants will have physical and psychological examinations, along with a blood sample. * After admission participants may be asked to stay awake for as long as
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 538 participants |
| Start Date | 2009-04-16 |
| Est. Completion | 2017-04-18 |
What the finished NCT00884702 record still lists
NCT00884702 is an observational study that tracks outcomes without assigning an intervention. The registered 538 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT00884702 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00884702 about?
NCT00884702 is a clinical study titled "Regional Rates of Cerebral Protein Synthesis: Effects of Sleep and Memory Consolidation". Background: * The brain needs sleep to function normally, but the purpose of sleep is not understood. Brain activity decreases during sleep, so it may be that sleep is important to maintain, repair, or reorganize brain cells. In animals, the formation of brain proteins increases during sleep, and t...
What is the current status of trial NCT00884702?
This trial is currently completed. The enrollment target is 538 participants. The study started on 2009-04-16. Estimated completion is 2017-04-18.
Who is sponsoring clinical trial NCT00884702?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
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