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NCT00845130 · ClinicalTrials.gov registry record · NA
Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes
A NA study of Type 2 Diabetes and Oxidative Stress, sponsored by In-Young Choi, Ph.D..
- Completed
- Registry status
- NA
- Development phase
- 42
- Enrollment target
- 1
- Study location
NCT00845130: Completed NA study of Type 2 Diabetes and Oxidative Stress, sponsored by In-Young Choi, Ph.D..
NCT00845130 is a NA study of Type 2 Diabetes and Oxidative Stress that has completed, run by In-Young Choi, Ph.D.. The registered enrollment target is 42 participants, below the 1,102-participant average among 288 other Type 2 Diabetes trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00845130, a NA study of Type 2 Diabetes and Oxidative Stress, has completed, sponsored by In-Young Choi, Ph.D..
- COMPLETED
- Registry status
- NA
- Development phase
- 42 participants
- Enrollment target
- 1
- Study location
Study Summary
Oxidative stress has been implicated in the development and complications of diabetes. Hyperglycemia and insulin resistance or insufficiency in diabetes can cause oxidative stress by excessive reactive oxygen species and can increase damage and alter antioxidant status in nerve cells. Antioxidant defense mechanisms protect against damage or restore oxidative damage. Glutathione, a powerful antioxidant plays a key role in the first line of antioxidant defense and seems to be a sensitive indicator of oxidative stress in various diseases such as diabetes. Glutathione functions in the regeneration of vitamin C which is another crucial antioxidant. Both hyperglycemia and insulin insufficiency inhibit uptake of vitamin C. The brain contains measurable amounts of glutathione that contribute to the antioxidant pool in the brain and guards against disease processes that are caused by oxidative stress. Since the brain is the most highly oxidative organ in the body and highly susceptible to oxidative stress, with increasing impact on diabetes, biomarkers of oxidative stress in the brain through the use of novel magnetic resonance imaging techniques for glutathione and vitamin C will be studied.
Conditions Studied
Interventions
- BIOLOGICAL ascorbic acid (Vitamin C)
Study Locations (1)
Kansas
- University of Kansas Medical Center - Kansas City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 42 participants |
| Start Date | 2009-09 |
| Est. Completion | 2014-12 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00845130
The ClinicalTrials.gov registry entry for NCT00845130 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 42 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,102-participant average among 288 other Type 2 Diabetes trials with a reported enrollment target (96% lower). The listed sponsor is In-Young Choi, Ph.D., which has 2 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Type 2 Diabetes appearing as the primary indexed condition, and to 1 intervention - of which ascorbic acid (Vitamin C) is the first listed.
NCT00845130 reports 1 study location spanning 1 distinct geographic area - top geographies include Kansas.
Frequently Asked Questions
What is clinical trial NCT00845130 about?
NCT00845130 is a clinical study titled "Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes". Oxidative stress has been implicated in the development and complications of diabetes. Hyperglycemia and insulin resistance or insufficiency in diabetes can cause oxidative stress by excessive reactive oxygen species and can increase damage and alter antioxidant status in nerve cells. Antioxidant de...
What is the current status of trial NCT00845130?
This trial is currently completed. It is a NA study. The enrollment target is 42 participants. The study started on 2009-09. Estimated completion is 2014-12.
What conditions does trial NCT00845130 study?
This clinical trial studies the following conditions: Type 2 Diabetes, Oxidative Stress.
What interventions are being tested in trial NCT00845130?
The interventions under investigation include: ascorbic acid (Vitamin C) (BIOLOGICAL).
Who is sponsoring clinical trial NCT00845130?
This trial is sponsored by In-Young Choi, Ph.D., which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00845130 being conducted?
This trial has 1 study location across Kansas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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