Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Chloroquine for Reducing Immune Activation in HIV- Infected Individuals
NCT00819390 · View on ClinicalTrials.gov ↗
Study Summary
HIV is characterized by frequent immune system activation. Early in the course of infection the body establishes an immune activation "set point" related to the amount of HIV in the blood stream. This set point affects the rate of CD4 cell loss. Without CD4 cells, or with very low levels of CD4 cells, the body cannot fight off illness. This is known as immunodeficiency. If left untreated HIV can lead to extreme immunodeficiency and AIDS. Evidence suggests that by decreasing the rate of immune system activation, immune deficiency progression could be prevented. The purpose of this study is to learn how well chloroquine can reduce the level of immune activation and to test the safety and tolerance of chloroquine in people infected with HIV.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Chloroquine
Study Locations (15)
Ohio
- Univ. of Cincinnati CRS (2401) — Cincinnati
- Case CRS (2501) — Cleveland
- MetroHealth CRS (2503) — Cleveland
Pennsylvania
- Hosp. of the Univ. of Pennsylvania CRS (6201) — Philadelphia
- Pittsburgh CRS (1001) — Pittsburgh
Alabama
- Alabama Therapeutics CRS (5801) — Birmingham
California
- Ucsd, Avrc Crs (701) — San Diego
Colorado
- University of Colorado Hospital CRS (6101) — Aurora
District of Columbia
- Georgetown University CRS (GU CRS) (1008) — Washington D.C.
Maryland
- Johns Hopkins Adult AIDS CRS (201) — Baltimore
Massachusetts
- Massachusetts General Hospital ACTG CRS (101) — Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2009-03 |
| Est. Completion | 2013-05 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00819390
The ClinicalTrials.gov registry entry for NCT00819390 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, which has 15 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with HIV Infections appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00819390 reports 15 study locations spanning 12 distinct geographic areas — top geographies include Ohio, Pennsylvania, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00819390 about?
NCT00819390 is a clinical study titled "Chloroquine for Reducing Immune Activation in HIV- Infected Individuals". HIV is characterized by frequent immune system activation. Early in the course of infection the body establishes an immune activation "set point" related to the amount of HIV in the blood stream. This set point affects the rate of CD4 cell loss. Without CD4 cells, or with very low levels of CD4 cell...
What is the current status of trial NCT00819390?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 70 participants. The study started on 2009-03. Estimated completion is 2013-05.
What conditions does trial NCT00819390 study?
This clinical trial studies the following conditions: HIV Infections. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00819390?
The interventions under investigation include: Placebo (DRUG), Chloroquine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00819390?
This trial is sponsored by Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, which has 15 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00819390 being conducted?
This trial has 15 study locations across Alabama, California, Colorado, District of Columbia, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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