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NCT00780442 · ClinicalTrials.gov registry record · Phase 2
D-Cycloserine and Cue Exposure in Cocaine-Dependent Individuals
A Phase 2 study of Cocaine Use Disorders, sponsored by Medical University of South Carolina.
- Completed
- Registry status
- Phase 2
- Development phase
- 27
- Enrollment target
- 1
- Study location
NCT00780442: Completed Phase 2 study of Cocaine Use Disorders, sponsored by Medical University of South Carolina.
NCT00780442 is a Phase 2 study of Cocaine Use Disorders that has completed, run by Medical University of South Carolina. The registered enrollment target is 27 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (80% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00780442, a Phase 2 study of Cocaine Use Disorders, has completed, sponsored by Medical University of South Carolina.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 27 participants
- Enrollment target
- 1
- Study location
Study Summary
In summary, this pilot study will explore the use of an innovative pharmacologic approach to the treatment of substance dependence through the facilitation of extinction of response to cocaine-conditioned cues in cocaine-dependent individuals. If DCS proves successful in this preliminary study, a controlled treatment trial will be planned. This novel approach could have implications for the treatment of multiple substance use disorders including methamphetamine, marijuana and opiate dependence.
Primary Outcome
Scale assess cocaine craving following cocaine cue exposure after two administrations of DCS. Subjects rate craving on a scale from 0-10 with 0 indicating "Not at all" and 10 indicating "Extremely".
Conditions Studied
Interventions
- DRUG Placebo
- DRUG D-cycloserine
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2006-09 |
| Est. Completion | 2008-07 |
| Phase | Phase 2 |
What the finished NCT00780442 record still lists
NCT00780442 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 27 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (80% lower).
The record links to 1 condition, with Cocaine Use Disorders appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT00780442 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT00780442 about?
NCT00780442 is a clinical study titled "D-Cycloserine and Cue Exposure in Cocaine-Dependent Individuals". In summary, this pilot study will explore the use of an innovative pharmacologic approach to the treatment of substance dependence through the facilitation of extinction of response to cocaine-conditioned cues in cocaine-dependent individuals. If DCS proves successful in this preliminary study, a co...
What is the current status of trial NCT00780442?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 27 participants. The study started on 2006-09. Estimated completion is 2008-07.
What conditions does trial NCT00780442 study?
This clinical trial studies the following conditions: Cocaine Use Disorders.
What interventions are being tested in trial NCT00780442?
The interventions under investigation include: Placebo (DRUG), D-cycloserine (DRUG).
Who is sponsoring clinical trial NCT00780442?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00780442 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cocaine Use Disorders
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00780442's enrollment target sits among peer trials
27 1697th of 2000 higher than 293 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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