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NCT00779324 · ClinicalTrials.gov registry record · NA
Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study
A NA study, sponsored by Wake Forest University Health Sciences.
- Completed
- Registry status
- NA
- Development phase
- 168
- Enrollment target
NCT00779324: Completed NA study, sponsored by Wake Forest University Health Sciences.
NCT00779324 is a NA study that has completed, run by Wake Forest University Health Sciences. The registered enrollment target is 168 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (88% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00779324, a NA study, has completed, sponsored by Wake Forest University Health Sciences.
- COMPLETED
- Registry status
- NA
- Development phase
- 168 participants
- Enrollment target
Study Summary
The purpose of this study is to study the effect of amantadine on irritability and aggression caused by traumatic brain injury.
Primary Outcome
The Neuropsychiatric Inventory (NPI) is a 40-item rating scale developed to assess 12 behavioral domains. Only the NPI-Irritability (NPI-I) domain was used for this study. NPI-I measures irritability with items including: bad temper, rapid mood changes, sudden anger, impatience, crankiness, argumentative. The rater selects the frequency (1-3) and severity (1-4) of the most problematic of these behavioral aspect(s) over the preceding month. The NPI score is the product of the frequency and severi
Interventions
- DRUG Placebo
- DRUG Amantadine Hydrochloride
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 168 participants |
| Start Date | 2009-08 |
| Est. Completion | 2013-05 |
| Phase | NA |
What the finished NCT00779324 record still lists
NCT00779324 is an interventional study that assigns participants to a tested intervention. The registered 168 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (88% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00779324 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00779324 about?
NCT00779324 is a clinical study titled "Amantadine for the Treatment of Traumatic Brain Injury Irritability and Aggression: A Multi-site Study". The purpose of this study is to study the effect of amantadine on irritability and aggression caused by traumatic brain injury.
What is the current status of trial NCT00779324?
This trial is currently completed. It is a NA study. The enrollment target is 168 participants. The study started on 2009-08. Estimated completion is 2013-05.
What interventions are being tested in trial NCT00779324?
The interventions under investigation include: Placebo (DRUG), Amantadine Hydrochloride (DRUG).
Who is sponsoring clinical trial NCT00779324?
This trial is sponsored by Wake Forest University Health Sciences, which has 1,140 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00779324's enrollment target sits among peer trials
168 619th of 2000 higher than 1,379 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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