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NCT00756236 · ClinicalTrials.gov registry record · NA
A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement
A NA study of Myocardial Ischemia, sponsored by University of Oklahoma.
- Completed
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT00756236: Completed NA study of Myocardial Ischemia, sponsored by University of Oklahoma.
NCT00756236 is a NA study of Myocardial Ischemia that has completed, run by University of Oklahoma. The registered enrollment target is 60 participants, below the 2,136-participant average among 29 other Myocardial Ischemia trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00756236, a NA study of Myocardial Ischemia, has completed, sponsored by University of Oklahoma.
- COMPLETED
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
We will compare three study groups receiving metoprolol, esmolol, or placebo. Level of anesthesia will be titrated to achieve the same range of BIS value in all groups. Our hypothesis is that the metoprolol and esmolol groups will require a lower level of anesthetic agent to achieve the targeted BIS range, compared to the placebo group. Our objective is to clarify if metoprolol, in a dose range used for perioperative cardiac protection, decreases anesthetic requirement.
Primary Outcome
We will measure the amount of Sevoflurane used to achieve the same level Bispectral Index. Each patient will have their percentage of sevoflurane in expired breath measured every 5 minutes for 2 hours, resulting in 24 data points per person. The primary endpoint will be area under the curve (AUC) for each subject for the first hour.
Conditions Studied
Interventions
- DRUG Metoprolol
- DRUG Esmolol
- DRUG P-Group
Study Locations (1)
Oklahoma
- Univeristy of Oklahoma Health Sciences Center Dept. Anesthesiology - Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2008-10 |
| Est. Completion | 2015-09-02 |
| Phase | NA |
What the finished NCT00756236 record still lists
NCT00756236 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 2,136-participant average among 29 other Myocardial Ischemia trials with a reported enrollment target (97% lower).
The record links to 1 condition, with Myocardial Ischemia appearing as the primary indexed condition, and to 3 interventions - of which Metoprolol is the first listed.
NCT00756236 reports a single indexed study location in Oklahoma.
Frequently Asked Questions
What is clinical trial NCT00756236 about?
NCT00756236 is a clinical study titled "A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement". We will compare three study groups receiving metoprolol, esmolol, or placebo. Level of anesthesia will be titrated to achieve the same range of BIS value in all groups. Our hypothesis is that the metoprolol and esmolol groups will require a lower level of anesthetic agent to achieve the targeted BIS...
What is the current status of trial NCT00756236?
This trial is currently completed. It is a NA study. The enrollment target is 60 participants. The study started on 2008-10. Estimated completion is 2015-09-02.
What conditions does trial NCT00756236 study?
This clinical trial studies the following conditions: Myocardial Ischemia.
What interventions are being tested in trial NCT00756236?
The interventions under investigation include: Metoprolol (DRUG), Esmolol (DRUG), P-Group (DRUG).
Who is sponsoring clinical trial NCT00756236?
This trial is sponsored by University of Oklahoma, which has 358 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00756236 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Myocardial Ischemia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00756236's enrollment target sits among peer trials
60 24th of 29 higher than 6 of 29 other Myocardial Ischemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Myocardial Ischemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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