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NCT00741858 · ClinicalTrials.gov registry record · Phase 3
Duragen Versus Duraguard in Chiari Surgery
A Phase 3 study, sponsored by University of Illinois at Chicago.
- Completed
- Registry status
- Phase 3
- Development phase
- 34
- Enrollment target
NCT00741858: Completed Phase 3 study, sponsored by University of Illinois at Chicago.
NCT00741858 is a Phase 3 study that has completed, run by University of Illinois at Chicago. The registered enrollment target is 34 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00741858, a Phase 3 study, has completed, sponsored by University of Illinois at Chicago.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 34 participants
- Enrollment target
Study Summary
The study evaluates two materials used for duraplasty of the posterior cranial fossa in treatment of Chiari malformation. One material (DuraGen) is a non-suturable collagen matrix that is applied over the defect if brain coverings (dura); the other (DuraGuard) is made out of bovine pericardium and has to be sutured during application. The study compares these two materials used for duraplasty of patients undergoing Chiari surgery in a prospective randomized fashion to check the rate of surgical complications associated with each material, patient's outcomes, length of surgery and the hospital stay, etc.
Primary Outcome
Physical health quality of life (based on SF-36 results) (SF-36 includes 8 scores scaled 0-100; lower score indicating more disability)
Interventions
- PROCEDURE Duragen duraplasty
- PROCEDURE Duraguard duraplasty
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 34 participants |
| Start Date | 2003-04 |
| Est. Completion | 2010-04 |
| Phase | Phase 3 |
What the finished NCT00741858 record still lists
NCT00741858 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 34 participants, a relatively small participant target, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 2 interventions - of which Duragen duraplasty is the first listed.
NCT00741858 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00741858 about?
NCT00741858 is a clinical study titled "Duragen Versus Duraguard in Chiari Surgery". The study evaluates two materials used for duraplasty of the posterior cranial fossa in treatment of Chiari malformation. One material (DuraGen) is a non-suturable collagen matrix that is applied over the defect if brain coverings (dura); the other (DuraGuard) is made out of bovine pericardium and h...
What is the current status of trial NCT00741858?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 34 participants. The study started on 2003-04. Estimated completion is 2010-04.
What interventions are being tested in trial NCT00741858?
The interventions under investigation include: Duragen duraplasty (PROCEDURE), Duraguard duraplasty (PROCEDURE).
Who is sponsoring clinical trial NCT00741858?
This trial is sponsored by University of Illinois at Chicago, which has 430 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00741858's enrollment target sits among peer trials
34 1905th of 2000 higher than 94 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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