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NCT00675038 · ClinicalTrials.gov registry record
Pilot Study of Non-Invasive Assessment of Hepatic And Myocardial Iron Through T2* Magnet Resonance Imaging (MRI) In Patients With Iron Overload
A clinical trial of Hematological Diseases, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- 52
- Enrollment target
- 1
- Study location
NCT00675038: Completed study of Hematological Diseases, sponsored by St. Jude Children's Research Hospital.
NCT00675038 is a study of Hematological Diseases that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 52 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00675038, a study of Hematological Diseases, has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- 52 participants
- Enrollment target
- 1
- Study location
Study Summary
Many hematological disorders are treated by giving red blood cells. Over a long period of time iron from the red blood cell will accumulate in the tissues of the heart, liver, and endocrine glands. This condition is referred to as iron overload and may become life threatening due to the effects of the iron on these tissues. The normal method for evaluation of iron overload is a liver biopsy. This procedure is invasive and has potential risks, such as bleeding and infection. It is very desirable to establish a method for assessing iron overload which is not invasive. New magnet resonance imaging (MRI) relaxation techniques (T2\*MRI) can be used to indirectly assess the liver iron content and iron in the heart. Results of T2\*MRIs show excellent correlation with liver iron content and heart function. The use of this method of assessment will minimize the risk and inconvenience of liver biopsy and possibly allow more frequent evaluations for iron overload, thus better treatment for these patients. Participants in this study will undergo both liver biopsy for liver iron content and T2\* MRI of the liver and the heart. Results from the procedures performed in this study will be compared, with the end result being the possible elimination of invasive procedures to diagnose iron overload.
Conditions Studied
Interventions
- PROCEDURE Liver Biopsy and MRI T2* MRI
Study Locations (1)
Tennessee
- St. Jude Children's Research Hospital - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 52 participants |
| Start Date | 2005-10 |
| Est. Completion | 2008-06 |
What the finished NCT00675038 record still lists
NCT00675038 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 52 participants, a relatively small participant target.
The record links to 1 condition, with Hematological Diseases appearing as the primary indexed condition, and to 1 intervention - of which Liver Biopsy and MRI T2* MRI is the first listed.
NCT00675038 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT00675038 about?
NCT00675038 is a clinical study titled "Pilot Study of Non-Invasive Assessment of Hepatic And Myocardial Iron Through T2* Magnet Resonance Imaging (MRI) In Patients With Iron Overload". Many hematological disorders are treated by giving red blood cells. Over a long period of time iron from the red blood cell will accumulate in the tissues of the heart, liver, and endocrine glands. This condition is referred to as iron overload and may become life threatening due to the effects of t...
What is the current status of trial NCT00675038?
This trial is currently completed. The enrollment target is 52 participants. The study started on 2005-10. Estimated completion is 2008-06.
What conditions does trial NCT00675038 study?
This clinical trial studies the following conditions: Hematological Diseases.
What interventions are being tested in trial NCT00675038?
The interventions under investigation include: Liver Biopsy and MRI T2* MRI (PROCEDURE).
Who is sponsoring clinical trial NCT00675038?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00675038 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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