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NCT00634036 · ClinicalTrials.gov registry record · Phase 2
Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics
A Phase 2 study of Asthma, sponsored by Fernando Holguin.
- Completed
- Registry status
- Phase 2
- Development phase
- 23
- Enrollment target
- 2
- Study locations
NCT00634036: Completed Phase 2 study of Asthma, sponsored by Fernando Holguin.
NCT00634036 is a Phase 2 study of Asthma that has completed, run by Fernando Holguin. The registered enrollment target is 23 participants, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (99% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00634036, a Phase 2 study of Asthma, has completed, sponsored by Fernando Holguin.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 23 participants
- Enrollment target
- 2
- Study locations
Study Summary
Asthmatics who are significantly overweight tend to have more severe symptoms, more flare ups, and are more likely to have poorly-controlled asthma when compared to other asthmatics. Researchers believe this occurs because excess adipose tissue (fat) in the body can cause higher-than-normal levels of leptin and lower-than-normal levels of adiponectin in the blood. The researchers of this study are testing a medication called pioglitazone in overweight asthmatics because they believe it can help regulate leptin and adiponectin and that this may improve symptoms of asthma.
Primary Outcome
Presence and degree of airway hyperresponsiveness assessed by methacholine challenge test. PC20= Methacholine dose at wich the FEV1 deops by \> 20% from pre-methacholine baseline values.
Conditions Studied
Interventions
- DRUG placebo
- DRUG pioglitazone
Study Locations (2)
Pennsylvania
- University of Pittsburgh - Pittsburgh
Vermont
- University of Vermont - Colchester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 23 participants |
| Start Date | 2009-10 |
| Est. Completion | 2012-04 |
| Phase | Phase 2 |
What the finished NCT00634036 record still lists
NCT00634036 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 23 participants, a relatively small participant target, below the 1,563-participant average among 374 other Asthma trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Asthma appearing as the primary indexed condition, and to 2 interventions - of which placebo is the first listed.
NCT00634036 reports a single indexed study location in Pennsylvania, Vermont.
Frequently Asked Questions
What is clinical trial NCT00634036 about?
NCT00634036 is a clinical study titled "Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics". Asthmatics who are significantly overweight tend to have more severe symptoms, more flare ups, and are more likely to have poorly-controlled asthma when compared to other asthmatics. Researchers believe this occurs because excess adipose tissue (fat) in the body can cause higher-than-normal levels ...
What is the current status of trial NCT00634036?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 23 participants. The study started on 2009-10. Estimated completion is 2012-04.
What conditions does trial NCT00634036 study?
This clinical trial studies the following conditions: Asthma.
What interventions are being tested in trial NCT00634036?
The interventions under investigation include: placebo (DRUG), pioglitazone (DRUG).
Who is sponsoring clinical trial NCT00634036?
This trial is sponsored by Fernando Holguin, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00634036 being conducted?
This trial has 2 study locations across Pennsylvania, Vermont. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Asthma
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00634036's enrollment target sits among peer trials
23 329th of 374 higher than 44 of 374 other Asthma trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Asthma trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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