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NCT00477659 · ClinicalTrials.gov registry record · Phase 4
Neural Correlates In Mild Alzheimer's Disease
A Phase 4 study, sponsored by Eisai.
- Completed
- Registry status
- Phase 4
- Development phase
- 14
- Enrollment target
NCT00477659: Completed Phase 4 study, sponsored by Eisai.
NCT00477659 is a Phase 4 study that has completed, run by Eisai. The registered enrollment target is 14 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00477659, a Phase 4 study, has completed, sponsored by Eisai.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 14 participants
- Enrollment target
Study Summary
The objective of this study was to identify neural correlates of cognitive improvement after 3 months of donepezil hydrochloride treatment using either or both of two functional magnetic resonance imaging (fMRI) measures - the functional Hippocampus Connectivity Index (HCI) and Cerebral Blood Flow (CBF) Perfusion; in the Medial Temporal Lobe (MTL) network in subjects in the early stage of Alzheimer's Disease (AD).
Primary Outcome
All neuroimaging procedures were performed on a research-dedicated GE 3.0 Tesla whole-body Excite scanner with 8-channel phase-array head coil. Resting-state functional magnetic resonance imaging (fMRI) of the medial temporal lobe (MTL) was performed. The functional HCI was derived from the MTL network using a data driven approach corresponding voxel time courses from the fMR images were processed to extract low frequency fluctuations. Functional connectivity was quantified by calculating the cr
Interventions
- DRUG Donepezil hydrochloride
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2007-07-23 |
| Est. Completion | 2008-08-15 |
| Phase | Phase 4 |
What the finished NCT00477659 record still lists
NCT00477659 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 14 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 1 intervention - of which Donepezil hydrochloride is the first listed.
NCT00477659 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00477659 about?
NCT00477659 is a clinical study titled "Neural Correlates In Mild Alzheimer's Disease". The objective of this study was to identify neural correlates of cognitive improvement after 3 months of donepezil hydrochloride treatment using either or both of two functional magnetic resonance imaging (fMRI) measures - the functional Hippocampus Connectivity Index (HCI) and Cerebral Blood Flow (...
What is the current status of trial NCT00477659?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 14 participants. The study started on 2007-07-23. Estimated completion is 2008-08-15.
What interventions are being tested in trial NCT00477659?
The interventions under investigation include: Donepezil hydrochloride (DRUG).
Who is sponsoring clinical trial NCT00477659?
This trial is sponsored by Eisai, which has 287 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00477659's enrollment target sits among peer trials
14 1901st of 2000 higher than 91 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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