Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

NCT00454090 · ClinicalTrials.gov registry record · Phase 1

AZD8330 First Time in Man in Patients With Advanced Malignancies

A Phase 1 study of Cancer, sponsored by AstraZeneca.

Completed
Registry status
Phase 1
Development phase
83
Enrollment target
3
Study locations

NCT00454090: Completed Phase 1 study of Cancer, sponsored by AstraZeneca.

NCT00454090 is a Phase 1 study of Cancer that has completed, run by AstraZeneca. The registered enrollment target is 83 participants, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (98% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.

View on ClinicalTrials.gov ↗

View your shortlist →

The verdict

NCT00454090, a Phase 1 study of Cancer, has completed, sponsored by AstraZeneca.

COMPLETED
Registry status
Phase 1
Development phase
83 participants
Enrollment target
3
Study locations

Study Summary

The primary purpose of this protocol is to investigate the safety and tolerability of AZD8330 (ARRY-424704) in patients with Advanced Malignancies

Conditions Studied

Interventions

  • DRUG AZD8330

Study Locations (3)

Pennsylvania

  • Research Site - Philadelphia

Texas

  • Research Site - Houston

Other

  • Research Site - Oslo

Trial Details

FieldValue
Enrollment Target 83 participants
Start Date 2007-03
Est. Completion 2011-03
Phase Phase 1
AstraZeneca

1,285 total trials

What the finished NCT00454090 record still lists

NCT00454090 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 83 participants, a relatively small participant target, below the 3,491-participant average among 615 other Cancer trials with a reported enrollment target (98% lower).

The record links to 1 condition, with Cancer appearing as the primary indexed condition, and to 1 intervention - of which AZD8330 is the first listed.

NCT00454090 reports a single indexed study location in Pennsylvania, Texas, Other.

Frequently Asked Questions

What is clinical trial NCT00454090 about?

NCT00454090 is a clinical study titled "AZD8330 First Time in Man in Patients With Advanced Malignancies". The primary purpose of this protocol is to investigate the safety and tolerability of AZD8330 (ARRY-424704) in patients with Advanced Malignancies

What is the current status of trial NCT00454090?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 83 participants. The study started on 2007-03. Estimated completion is 2011-03.

What conditions does trial NCT00454090 study?

This clinical trial studies the following conditions: Cancer.

What interventions are being tested in trial NCT00454090?

The interventions under investigation include: AZD8330 (DRUG).

Who is sponsoring clinical trial NCT00454090?

This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00454090 being conducted?

This trial has 3 study locations across Pennsylvania, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Similar trials for Cancer

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00454090's enrollment target sits among peer trials

83 347th of 615 higher than 268 of 615 other Cancer trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

Nationwide trials with similar profiles

Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.

Similar enrollment target

  • NCT02974647 · 83 participants · Phase 2

    Study of Ruxolitinib in Relapsed or Refractory T or NK Cell Lymphoma

  • NCT03919292 · 83 participants · Phase 1

    Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca

  • NCT04626674 · 83 participants · Phase 1

    A Gene Transfer Therapy Study to Evaluate the Safety of and Expression From Delandistrogene Moxeparvovec (SRP-9001) in Participants With Duchenne Muscular Dystrophy (DMD)

  • NCT05277168 · 83 participants · Phase 1

    A Trial TO Evaluate THE Safety, Tolerability, Pharmacokinetics, AND Efficacy OF Shr-a1904 IN Subjects With Advanced Solid Tumors

Similar registry start date

  • NCT05988463 · started 2027-01-01 · Phase 1

    Dose-Escalation Study of Artesunate Patients With IPF

  • NCT07219706 · started 2026-12-10 · NA

    Dietary Fiber and Time Restricted Eating

  • NCT02831335 · started 2026-12-01

    Technical Development of Multi-Parametric Renocerebral MRI

  • NCT05962346 · started 2026-12 · NA

    Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia

Source: ClinicalTrials.gov NCT00454090, the US trial registry maintained by the National Library of Medicine. NCT00454090 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.