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NCT00442130 · ClinicalTrials.gov registry record · Phase 1
Reduced Intensity Stem Cell Transplantation for Chronic Lymphocytic Leukemia Followed by Vaccination
A Phase 1 study, sponsored by Dana-Farber Cancer Institute.
- Completed
- Registry status
- Phase 1
- Development phase
- 27
- Enrollment target
NCT00442130: Completed Phase 1 study, sponsored by Dana-Farber Cancer Institute.
NCT00442130 is a Phase 1 study that has completed, run by Dana-Farber Cancer Institute. The registered enrollment target is 27 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (55% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00442130, a Phase 1 study, has completed, sponsored by Dana-Farber Cancer Institute.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 27 participants
- Enrollment target
Study Summary
The purpose of this research study is to assess the safety and immune activity of a vaccine made from the participant's own cancer cells, when administered after a reduced intensity transplant. In recent years, researchers at Dana-Farber Cancer Institute have discovered that vaccines made from a patients's own cancer cells, that have been engineered in the laboratory to produce a protein called GM-CSF, can be effective in stimulating a powerful immune response specific to that cancer.
Interventions
- PROCEDURE stem cell transplantation
- BIOLOGICAL GM-K562 vaccine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 27 participants |
| Start Date | 2007-02 |
| Est. Completion | 2020-04 |
| Phase | Phase 1 |
What the finished NCT00442130 record still lists
NCT00442130 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 27 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (55% lower).
The record links to 0 conditions, and to 2 interventions - of which stem cell transplantation is the first listed.
NCT00442130 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00442130 about?
NCT00442130 is a clinical study titled "Reduced Intensity Stem Cell Transplantation for Chronic Lymphocytic Leukemia Followed by Vaccination". The purpose of this research study is to assess the safety and immune activity of a vaccine made from the participant's own cancer cells, when administered after a reduced intensity transplant. In recent years, researchers at Dana-Farber Cancer Institute have discovered that vaccines made from a pat...
What is the current status of trial NCT00442130?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 27 participants. The study started on 2007-02. Estimated completion is 2020-04.
What interventions are being tested in trial NCT00442130?
The interventions under investigation include: stem cell transplantation (PROCEDURE), GM-K562 vaccine (BIOLOGICAL).
Who is sponsoring clinical trial NCT00442130?
This trial is sponsored by Dana-Farber Cancer Institute, which has 781 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00442130's enrollment target sits among peer trials
27 1463rd of 2000 higher than 519 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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