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COMPLETED Phase 2

Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's Lymphoma

NCT00392834 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving rituximab together with combination chemotherapy may kill more cancer cells. PURPOSE: This phase II trial is studying how well giving rituximab together with combination chemotherapy works in treating patients with newly diagnosed, HIV-associated Burkitt's lymphoma.

Conditions Studied

Interventions

  • DRUG cyclophosphamide
  • BIOLOGICAL rituximab
  • BIOLOGICAL filgrastim
  • DRUG cytarabine
  • BIOLOGICAL pegfilgrastim

Study Locations (13)

California

  • Rebecca and John Moores UCSD Cancer Center — La Jolla
  • USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles
  • UCLA Clinical AIDS Research and Education (CARE) Center — Los Angeles
  • UCSF Medical Center at Parnassus — San Francisco

New York

  • Memorial Sloan-Kettering Cancer Center — New York
  • Albert Einstein Cancer Center at Albert Einstein College of Medicine — The Bronx

Maryland

  • Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore

Massachusetts

  • Beth Israel Deaconess Medical Center — Boston

Missouri

  • Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis — St Louis

Ohio

  • Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center — Columbus

Pennsylvania

  • Pennsylvania Oncology Hematology Associates, Incorporated - Philadelphia — Philadelphia

Washington

  • Floyd and Delores Jones Cancer Institute at Virginia Mason Medical Center — Seattle

Trial Details

FieldValue
Enrollment Target 34 participants
Start Date 2006-09
Est. Completion 2013-07
Phase Phase 2

Sponsor

AIDS Malignancy Consortium

11 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00392834

The ClinicalTrials.gov registry entry for NCT00392834 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 34 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AIDS Malignancy Consortium, which has 11 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Lymphoma appearing as the primary indexed condition, and to 5 interventions — of which cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00392834 reports 13 study locations spanning 9 distinct geographic areas — top geographies include California, New York, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00392834 about?

NCT00392834 is a clinical study titled "Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's Lymphoma". RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Drugs used in chemotherapy work in different ways to stop...

What is the current status of trial NCT00392834?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 34 participants. The study started on 2006-09. Estimated completion is 2013-07.

What conditions does trial NCT00392834 study?

This clinical trial studies the following conditions: Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00392834?

The interventions under investigation include: cyclophosphamide (DRUG), rituximab (BIOLOGICAL), filgrastim (BIOLOGICAL), cytarabine (DRUG), pegfilgrastim (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00392834?

This trial is sponsored by AIDS Malignancy Consortium, which has 11 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00392834 being conducted?

This trial has 13 study locations across California, Maryland, Massachusetts, Missouri, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial