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NCT00385762 · ClinicalTrials.gov registry record
SSRI Effects on Semen Parameters in Men
A clinical trial, sponsored by Weill Medical College of Cornell University.
- Completed
- Registry status
- 35
- Enrollment target
NCT00385762 is a clinical trial that has completed, run by Weill Medical College of Cornell University. The registered enrollment target is 35 participants.
The verdict
NCT00385762 has completed, sponsored by Weill Medical College of Cornell University.
- COMPLETED
- Registry status
- 35 participants
- Enrollment target
Study Summary
According to the National Institute of Mental Health, depressive disorders afflict over six million U.S. men annually. Most cases of moderate or severe depression are treated with antidepressants, including monoamine oxidase inhibitors, tricyclic antidepressants, and, more recently, selective serotonin reuptake inhibitors (SSRIs) and antidepressants with modest serotonin and norepinephrine reuptake inhibition but unknown mechanism-of-action. Over the past two years, prescribing data show a steady increase in antidepressant dispensing rates (especially including serotonin reuptake inhibitors) for adults. SSRIs are known to have an effect on ejaculatory function and are therapeutically used for treatment of premature (rapid) ejaculation. However, few studies have evaluated the potential impact of antidepressant medications on male fertility, and no studies have been published with respect to the impact of newer antidepressants, such as SSRIs, on male fertility. In the high-volume male infertility practice at New York Hospital-Cornell Medical Center, several patients have presented who have had a clear temporal association between SSRI use and impairment in sperm motility and/or sperm transport (emission). These men have shown improvement in sperm counts and motility after discontinuation of antidepressant medications.
Interventions
- DRUG paroxetine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 35 participants |
| Start Date | 2007-01 |
| Est. Completion | 2007-09 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00385762
The ClinicalTrials.gov registry entry for NCT00385762 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 35 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Weill Medical College of Cornell University, which has 701 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which paroxetine is the first listed.
NCT00385762 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00385762 about?
NCT00385762 is a clinical study titled "SSRI Effects on Semen Parameters in Men". According to the National Institute of Mental Health, depressive disorders afflict over six million U.S. men annually. Most cases of moderate or severe depression are treated with antidepressants, including monoamine oxidase inhibitors, tricyclic antidepressants, and, more recently, selective seroto...
What is the current status of trial NCT00385762?
This trial is currently completed. The enrollment target is 35 participants. The study started on 2007-01. Estimated completion is 2007-09.
What interventions are being tested in trial NCT00385762?
The interventions under investigation include: paroxetine (DRUG).
Who is sponsoring clinical trial NCT00385762?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
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