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NCT00346632 · ClinicalTrials.gov registry record · Phase 1
An Ascending Dose Study of KW-2449 in Acute Leukemias, Myelodysplastic Syndromes, and Chronic Myelogenous Leukemia
A Phase 1 study, sponsored by Kyowa Kirin.
- Terminated
- Registry status
- Phase 1
- Development phase
- 37
- Enrollment target
NCT00346632: Clinical Trial Phase 1 study, sponsored by Kyowa Kirin.
NCT00346632 is a Phase 1 study that was terminated before completion, run by Kyowa Kirin. The registered enrollment target is 37 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (38% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00346632, a Phase 1 study, was terminated before completion, sponsored by Kyowa Kirin.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 37 participants
- Enrollment target
Study Summary
Non-randomized, open, dose ranging and dose scheduling study of ascending doses of KW-2449 in subjects with AML, ALL, MDS and CML.
Primary Outcome
In addition to the number of TEAEs, the number of serious TEAEs, the number of related TEAEs, the number of Grade 3-4 TEAEs, and the number of subjects who died or discontinued due to TEAEs were also assessed. The maximally tolerated dose (MTD) was also to be determined, but it was not actually reached in either arm.
Interventions
- DRUG KW-2449
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 37 participants |
| Start Date | 2006-06 |
| Est. Completion | 2008-04 |
| Phase | Phase 1 |
Why NCT00346632 stopped before completion
NCT00346632 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 37 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (38% lower).
The record links to 0 conditions, and to 1 intervention - of which KW-2449 is the first listed.
NCT00346632 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00346632 about?
NCT00346632 is a clinical study titled "An Ascending Dose Study of KW-2449 in Acute Leukemias, Myelodysplastic Syndromes, and Chronic Myelogenous Leukemia". Non-randomized, open, dose ranging and dose scheduling study of ascending doses of KW-2449 in subjects with AML, ALL, MDS and CML.
What is the current status of trial NCT00346632?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 37 participants. The study started on 2006-06. Estimated completion is 2008-04.
What interventions are being tested in trial NCT00346632?
The interventions under investigation include: KW-2449 (DRUG).
Who is sponsoring clinical trial NCT00346632?
This trial is sponsored by Kyowa Kirin, which has 34 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00346632's enrollment target sits among peer trials
37 1204th of 2000 higher than 791 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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