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NCT00339404 · ClinicalTrials.gov registry record
Genetic Analysis of Familial Melanoma
A clinical trial, sponsored by National Human Genome Research Institute (NHGRI).
- Completed
- Registry status
- 3,000
- Enrollment target
NCT00339404 is a clinical trial that has completed, run by National Human Genome Research Institute (NHGRI). The registered enrollment target is 3,000 participants.
The verdict
NCT00339404 has completed, sponsored by National Human Genome Research Institute (NHGRI).
- COMPLETED
- Registry status
- 3,000 participants
- Enrollment target
Study Summary
In collaboration with members of The International Melanoma Consortium, we propose to study melanoma in families lacking mutations in the cyclin-dependent kinase inhibitor 2 (CDKN2 or p16) gene, or the cyclin-dependant kinase 4 (CDK4). CDKN2 and CDK4 are both genes that encode presumed tumor suppressor genes, mutant forms of which are known to cause increased susceptibility to melanoma. The purpose of the present study then is to confirm the existence of and to identify additional gene(s) involved in heritable melanoma (cutaneous and ocular) and their precursor lesions (atypical nevi) by linkage analysis and gene mapping strategies. It is clear that the risk to develop atypical nevi and/or melanoma is strongly influenced by genetic and environmental factors (e.g. sun exposure). Characterization of such genes could provide important insights into the inheritance, pathogenesis, and treatment of this increasingly important disease.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3,000 participants |
| Start Date | 1999-03-04 |
| Est. Completion | 2011-03-07 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00339404
The ClinicalTrials.gov registry entry for NCT00339404 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 3,000 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Human Genome Research Institute (NHGRI), which has 185 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT00339404 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00339404 about?
NCT00339404 is a clinical study titled "Genetic Analysis of Familial Melanoma". In collaboration with members of The International Melanoma Consortium, we propose to study melanoma in families lacking mutations in the cyclin-dependent kinase inhibitor 2 (CDKN2 or p16) gene, or the cyclin-dependant kinase 4 (CDK4). CDKN2 and CDK4 are both genes that encode presumed tumor suppres...
What is the current status of trial NCT00339404?
This trial is currently completed. The enrollment target is 3,000 participants. The study started on 1999-03-04. Estimated completion is 2011-03-07.
Who is sponsoring clinical trial NCT00339404?
This trial is sponsored by National Human Genome Research Institute (NHGRI), which has 185 total clinical trials registered on ClinicalTrials.gov.
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