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NCT00339352 · ClinicalTrials.gov registry record
A Family Study of Adults With Glioma
A clinical trial, sponsored by National Institutes of Health Clinical Center (CC).
- Completed
- Registry status
- 1,871
- Enrollment target
NCT00339352: Completed study, sponsored by National Institutes of Health Clinical Center (CC).
NCT00339352 is a clinical trial that has completed, run by National Institutes of Health Clinical Center (CC). The registered enrollment target is 1,871 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00339352 has completed, sponsored by National Institutes of Health Clinical Center (CC).
- COMPLETED
- Registry status
- 1,871 participants
- Enrollment target
Study Summary
To advance understanding of environmental, behavioral and genetic causes of brain tumors in adults, DCEG investigators initiated a multicenter case-control study of malignant and benign tumors in adults in 1994. This four-year study was conducted at participating hospitals in Boston, Phoenix, and Pittsburgh. Eligible cases were individuals greater than or equal to 18 years newly diagnosed with an intracranial glioma, meningioma or acoustic neuroma and treated at one of the participating hospitals. The controls were patients admitted to neurological, neurosurgical or general surgical services at the same three hospitals for any of a variety of non-neoplastic conditions. By the end of the study, 811 brain tumor cases had been accrued. Information about a broad range of possible environmental, lifestyle, and genetic risk factors was obtained from both cases and controls through a computer-assisted personal interview (CAPI). The family history component obtained history and age at diagnosis of cancer or benign brain tumors and selected other diseases, for all living and deceased first degree relatives. A supplemental self-administered questionnaire covered diet, vitamin supplements, alcohol consumption, and household use of electrical appliances. Blood samples were obtained as a source of DNA. Currently, data analysis is in the early stages. To increase our ability to examine both genetic and environmental components of brain tumor risk, we decided to add a family studies component to the case-control study, focusing on families of glioma cases. Initial contact with each family is made through the cases or, if a case is deceased, through the next of kin. Cases or next of kin are asked to complete a Family Health Questionnaire that updates the family medical history and provides contacting information for all adult first degree relatives and more distant relatives with cancer. Then, we contact all first degree relatives greater than or equal to age 18 years, and the ne
Primary Outcome
Genetic susceptibility genes
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,871 participants |
| Start Date | 1999-03-11 |
| Est. Completion | 2020-12-03 |
What the finished NCT00339352 record still lists
NCT00339352 is an observational study that tracks outcomes without assigning an intervention. Its 1,871 participants enrollment target places it among the larger protocols in the corpus.
The record links to 0 conditions, and to 0 interventions.
NCT00339352 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00339352 about?
NCT00339352 is a clinical study titled "A Family Study of Adults With Glioma". To advance understanding of environmental, behavioral and genetic causes of brain tumors in adults, DCEG investigators initiated a multicenter case-control study of malignant and benign tumors in adults in 1994. This four-year study was conducted at participating hospitals in Boston, Phoenix, and Pi...
What is the current status of trial NCT00339352?
This trial is currently completed. The enrollment target is 1,871 participants. The study started on 1999-03-11. Estimated completion is 2020-12-03.
Who is sponsoring clinical trial NCT00339352?
This trial is sponsored by National Institutes of Health Clinical Center (CC), which has 338 total clinical trials registered on ClinicalTrials.gov.
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