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NCT00287365 · ClinicalTrials.gov registry record · NA
Genetic Susceptibility to Ozone in Mild Asthmatic Volunteers
A NA study, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- NA
- Development phase
- 25
- Enrollment target
NCT00287365 is a NA study that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 25 participants.
The verdict
NCT00287365, a NA study, has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- NA
- Development phase
- 25 participants
- Enrollment target
Study Summary
Recent reports have shown that people with asthma who have a particular gene, known as the GSTM1 null gene, are more susceptible to the effect of air pollutants. The purpose of this research study is to learn if volunteers who have asthma and have a GSTM1 null gene have increased response (change in lung function and increase in lung cells collected from sputum) compared to volunteers with asthma who have the GSTM1 sufficient gene when challenged with 0.4 ppm ozone during intermittent exercise. The principal purpose of this study is to identify hyper-responsive, responsive and non-responsive groups of human subjects with mild asthma based on their airway neutrophilic response to ozone exposure, and to perform analyses on DNA from airway cells to explore possible differences in genetic profiles between the three groups. An additional pilot aim is to compare expression of a small number of specific genes of interest in a subset of ozone-responsive and ozone-non-responsive subjects with mild asthma.
Interventions
- DRUG ozone
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2006-01 |
| Est. Completion | 2015-11 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00287365
The ClinicalTrials.gov registry entry for NCT00287365 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 25 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of North Carolina, Chapel Hill, which has 1,109 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which ozone is the first listed.
NCT00287365 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00287365 about?
NCT00287365 is a clinical study titled "Genetic Susceptibility to Ozone in Mild Asthmatic Volunteers". Recent reports have shown that people with asthma who have a particular gene, known as the GSTM1 null gene, are more susceptible to the effect of air pollutants. The purpose of this research study is to learn if volunteers who have asthma and have a GSTM1 null gene have increased response (change in...
What is the current status of trial NCT00287365?
This trial is currently completed. It is a NA study. The enrollment target is 25 participants. The study started on 2006-01. Estimated completion is 2015-11.
What interventions are being tested in trial NCT00287365?
The interventions under investigation include: ozone (DRUG).
Who is sponsoring clinical trial NCT00287365?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
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