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NCT00279864 · ClinicalTrials.gov registry record
The Utility of Levofloxacin-Rifampin in the Therapy of Prosthetic Joint Infection
A clinical trial of Staphylococcal Infection and Staphylococcus Aureus Prosthetic Joint Infection, sponsored by Mayo Clinic.
- Completed
- Registry status
- 15
- Enrollment target
- 1
- Study location
NCT00279864 is a study of Staphylococcal Infection and Staphylococcus Aureus Prosthetic Joint Infection that has completed, run by Mayo Clinic. The registered enrollment target is 15 participants. The trial reports 1 study location across 1 state.
The verdict
NCT00279864, a study of Staphylococcal Infection and Staphylococcus Aureus Prosthetic Joint Infection, has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
Prosthetic joint infection is a devastating complication of total joint arthroplasty ultimately leading to the failure of the total joint arthroplasty function and possibly death. Optimal treatment requires the resection of the infected total joint arthroplasty followed by prolonged parenteral antimicrobial therapy. This procedure is followed by reimplantation of a new total joint arthroplasty at a later date. Surgical debridement and retention of the infected total joint arthroplasty offers a more conservative surgical approach and has been proven to be cost-effective in selected groups of patients. Traditional medical therapy for staphylococcal infection would require an initial parenteral antimicrobial followed by chronic oral non-rifampin containing antimicrobial suppression regimen for the life of the total joint arthroplasty. With this strategy the success rate is close to 30%. Recently, several prospective studies of patients with THA, TKA and fracture fixation device infections conducted in Europe showed that the success rate with a 3-6 month course of a quinolone-rifampin combination is effective in 70% to 100% of cases. The proposed study will be a prospective open label observational cohort that will evaluate the outcome of Patients with S. aureus PJI treated with a medical regimen that includes oral levofloxacin- rifampin and debridement and retention of components. This medical regimen was approved for use by the Orthopedic Infectious Diseases focus group, Mayo Clinic, Rochester. 15 patients will be enrolled over a one-year period and followed up to minimum of 1 additional year. The outcome of this group will be compared to a historical group that is treated with traditional therapy.
Conditions Studied
Study Locations (1)
Minnesota
- Mayo Clinic - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2005-09 |
| Est. Completion | 2007-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00279864
The ClinicalTrials.gov registry entry for NCT00279864 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Mayo Clinic, which has 2,844 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Staphylococcal Infection appearing as the primary indexed condition, and to 0 interventions.
NCT00279864 reports 1 study location spanning 1 distinct geographic area - top geographies include Minnesota.
Frequently Asked Questions
What is clinical trial NCT00279864 about?
NCT00279864 is a clinical study titled "The Utility of Levofloxacin-Rifampin in the Therapy of Prosthetic Joint Infection". Prosthetic joint infection is a devastating complication of total joint arthroplasty ultimately leading to the failure of the total joint arthroplasty function and possibly death. Optimal treatment requires the resection of the infected total joint arthroplasty followed by prolonged parenteral antim...
What is the current status of trial NCT00279864?
This trial is currently completed. The enrollment target is 15 participants. The study started on 2005-09. Estimated completion is 2007-01.
What conditions does trial NCT00279864 study?
This clinical trial studies the following conditions: Staphylococcal Infection, Staphylococcus Aureus Prosthetic Joint Infection.
Who is sponsoring clinical trial NCT00279864?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00279864 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Staphylococcal Infection
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Staphylococcus Aureus Prosthetic Joint Infection
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