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NCT00274937 · ClinicalTrials.gov registry record · Phase 3
Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer
A Phase 3 study of Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 and Stage IV Nasopharyngeal Undifferentiated Carcinoma AJCC v7, sponsored by Children's Oncology Group.
- Completed
- Registry status
- Phase 3
- Development phase
- 111
- Enrollment target
- 20
- Study locations
NCT00274937 is a Phase 3 study of Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 and Stage IV Nasopharyngeal Undifferentiated Carcinoma AJCC v7 that has completed, run by Children's Oncology Group. The registered enrollment target is 111 participants. The trial reports 20 study locations across 7 states.
The verdict
NCT00274937, a Phase 3 study of Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 and Stage IV Nasopharyngeal Undifferentiated Carcinoma AJCC v7, has completed, sponsored by Children's Oncology Group.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 111 participants
- Enrollment target
- 20
- Study locations
Study Summary
This phase III trial is studying how well radiation therapy, amifostine, and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as amifostine, may protect normal cells from the side effects of radiation therapy. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with amifostine and chemotherapy may kill more tumor cells.
Conditions Studied
Interventions
- DRUG Cisplatin
- DRUG Fluorouracil
- OTHER Laboratory Biomarker Analysis
- RADIATION Radiation Therapy
- DRUG Amifostine
Study Locations (20)
California
- Kaiser Permanente Downey Medical Center - Downey
- Children's Hospital Los Angeles - Los Angeles
- Mattel Children's Hospital UCLA - Los Angeles
- UCLA / Jonsson Comprehensive Cancer Center - Los Angeles
- Valley Children's Hospital - Madera
- Kaiser Permanente-Oakland - Oakland
- Lucile Packard Children's Hospital Stanford University - Palo Alto
- UCSF Medical Center-Mount Zion - San Francisco
- UCSF Medical Center-Parnassus - San Francisco
- UCSF Medical Center-Mission Bay - San Francisco
Alabama
- Children's Hospital of Alabama - Birmingham
- University of Alabama at Birmingham Cancer Center - Birmingham
Arkansas
- Arkansas Children's Hospital - Little Rock
- University of Arkansas for Medical Sciences - Little Rock
Connecticut
- University of Connecticut - Farmington
- Connecticut Children's Medical Center - Hartford
District of Columbia
- MedStar Georgetown University Hospital - Washington D.C.
- Children's National Medical Center - Washington D.C.
Arizona
- Banner University Medical Center - Tucson - Tucson
Colorado
- Children's Hospital Colorado - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 111 participants |
| Start Date | 2006-02-20 |
| Est. Completion | 2022-09-30 |
| Phase | Phase 3 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00274937
The ClinicalTrials.gov registry entry for NCT00274937 describes a study currently listed as completed, categorized as Phase 3. The registered enrollment target is 111 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Children's Oncology Group, which has 342 total studies on file at ClinicalTrials.gov.
The record links to 8 conditions, with Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 appearing as the primary indexed condition, and to 5 interventions - of which Cisplatin is the first listed.
NCT00274937 reports 20 study locations spanning 7 distinct geographic areas - top geographies include California, Alabama, Arkansas.
Frequently Asked Questions
What is clinical trial NCT00274937 about?
NCT00274937 is a clinical study titled "Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer". This phase III trial is studying how well radiation therapy, amifostine, and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as amifostine, may protect normal cells from the side effec...
What is the current status of trial NCT00274937?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 111 participants. The study started on 2006-02-20. Estimated completion is 2022-09-30.
What conditions does trial NCT00274937 study?
This clinical trial studies the following conditions: Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7, Stage IV Nasopharyngeal Undifferentiated Carcinoma AJCC v7, Stage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7, Stage I Nasopharyngeal Undifferentiated Carcinoma AJCC v7, Stage II Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7.
What interventions are being tested in trial NCT00274937?
The interventions under investigation include: Cisplatin (DRUG), Fluorouracil (DRUG), Laboratory Biomarker Analysis (OTHER), Radiation Therapy (RADIATION), Amifostine (DRUG).
Who is sponsoring clinical trial NCT00274937?
This trial is sponsored by Children's Oncology Group, which has 342 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00274937 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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