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Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (F.A.M.E.)
NCT00267774 · View on ClinicalTrials.gov ↗
Study Summary
In this multicenter, international study we are evaluating two approaches to determine which coronary artery narrowings require stent placement in patients with multivessel coronary artery disease. Patients will be randomized to an angiographic strategy, where only coronary angiography is used to determine which lesions to stent or to a pressure wire strategy where fractional flow reserve, an index measured with the pressure wire, will be used to determine which lesions to stent. The primary outcome will be major adverse cardiac events at 1 year. A secondary outcome will be cost-effectiveness.
Conditions Studied
Interventions
- DEVICE Fractional flow reserve
- PROCEDURE Angio-guided PCI
Study Locations (2)
California
- Stanford University School of Medicine — Stanford
Other
- Catharina Hospital — Eindhoven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,005 participants |
| Start Date | 2006-01 |
| Est. Completion | 2015-09 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00267774
The ClinicalTrials.gov registry entry for NCT00267774 describes a study currently listed as completed. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,005 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Stanford University, which has 1,643 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Coronary Arteriosclerosis appearing as the primary indexed condition, and to 2 interventions — of which Fractional flow reserve is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00267774 reports 2 study locations spanning 2 distinct geographic areas — top geographies include California, Other. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00267774 about?
NCT00267774 is a clinical study titled "Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (F.A.M.E.)". In this multicenter, international study we are evaluating two approaches to determine which coronary artery narrowings require stent placement in patients with multivessel coronary artery disease. Patients will be randomized to an angiographic strategy, where only coronary angiography is used to de...
What is the current status of trial NCT00267774?
This trial is currently completed. It is a NA study. The enrollment target is 1,005 participants. The study started on 2006-01. Estimated completion is 2015-09.
What conditions does trial NCT00267774 study?
This clinical trial studies the following conditions: Coronary Arteriosclerosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00267774?
The interventions under investigation include: Fractional flow reserve (DEVICE), Angio-guided PCI (PROCEDURE). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00267774?
This trial is sponsored by Stanford University, which has 1,643 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00267774 being conducted?
This trial has 2 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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