Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00267774 · ClinicalTrials.gov registry record · NA
Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (F.A.M.E.)
A NA study of Coronary Arteriosclerosis, sponsored by Stanford University.
- Completed
- Registry status
- NA
- Development phase
- 1,005
- Enrollment target
- 2
- Study locations
NCT00267774: Completed NA study of Coronary Arteriosclerosis, sponsored by Stanford University.
NCT00267774 is a NA study of Coronary Arteriosclerosis that has completed, run by Stanford University. The registered enrollment target is 1,005 participants, above the 626-participant average among 11 other Coronary Arteriosclerosis trials with a reported enrollment target (61% higher). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00267774, a NA study of Coronary Arteriosclerosis, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- NA
- Development phase
- 1,005 participants
- Enrollment target
- 2
- Study locations
Study Summary
In this multicenter, international study we are evaluating two approaches to determine which coronary artery narrowings require stent placement in patients with multivessel coronary artery disease. Patients will be randomized to an angiographic strategy, where only coronary angiography is used to determine which lesions to stent or to a pressure wire strategy where fractional flow reserve, an index measured with the pressure wire, will be used to determine which lesions to stent. The primary outcome will be major adverse cardiac events at 1 year. A secondary outcome will be cost-effectiveness.
Primary Outcome
All cause death, Documented myocardial infarction, Repeat revascularization (PCI and/or CABG) as adjudicated by the Clinical Event Committee
Conditions Studied
Interventions
- DEVICE Fractional flow reserve
- PROCEDURE Angio-guided PCI
Study Locations (2)
California
- Stanford University School of Medicine - Stanford
Other
- Catharina Hospital - Eindhoven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,005 participants |
| Start Date | 2006-01 |
| Est. Completion | 2015-09 |
| Phase | NA |
What the finished NCT00267774 record still lists
NCT00267774 is an interventional study that assigns participants to a tested intervention. Its 1,005 participants enrollment target places it among the larger protocols in the corpus, above the 626-participant average among 11 other Coronary Arteriosclerosis trials with a reported enrollment target (61% higher).
The record links to 1 condition, with Coronary Arteriosclerosis appearing as the primary indexed condition, and to 2 interventions - of which Fractional flow reserve is the first listed.
NCT00267774 reports a single indexed study location in California, Other.
Frequently Asked Questions
What is clinical trial NCT00267774 about?
NCT00267774 is a clinical study titled "Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (F.A.M.E.)". In this multicenter, international study we are evaluating two approaches to determine which coronary artery narrowings require stent placement in patients with multivessel coronary artery disease. Patients will be randomized to an angiographic strategy, where only coronary angiography is used to de...
What is the current status of trial NCT00267774?
This trial is currently completed. It is a NA study. The enrollment target is 1,005 participants. The study started on 2006-01. Estimated completion is 2015-09.
What conditions does trial NCT00267774 study?
This clinical trial studies the following conditions: Coronary Arteriosclerosis.
What interventions are being tested in trial NCT00267774?
The interventions under investigation include: Fractional flow reserve (DEVICE), Angio-guided PCI (PROCEDURE).
Who is sponsoring clinical trial NCT00267774?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00267774 being conducted?
This trial has 2 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Coronary Arteriosclerosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00267774's enrollment target sits among peer trials
1,005 3rd of 11 higher than 9 of 11 other Coronary Arteriosclerosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Coronary Arteriosclerosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging Technique
ACTIVE NOT RECRUITING · NA
-
Coronary Atherosclerosis Evaluation by Arterial Wall Magnetic Resonance Imaging (MRI)
COMPLETED · NA
-
Combined Behavioral and Pharmacological Intervention for Cardiovascular Risk Reduction in Diabetic Patients
COMPLETED · NA
-
HARMONEE - Japan-USA Harmonized Assessment by Randomized, Multi-Center Study of OrbusNEich's Combo StEnt
COMPLETED · NA
-
GRAVITAS: Gauging Responsiveness With A VerifyNow Assay-Impact On Thrombosis And Safety
COMPLETED · NA
-
Multidisciplinary Inpatient Palliative Care Intervention
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04389632 · 1,006 participants · Phase 1
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
- NCT07191782 · 1,008 participants · NA
Examining the Efficacy of the PRAISE With Coaching Program
- NCT06207864 · 1,001 participants · NA
Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing
- NCT00018044 · 1,000 participants
Study of Mycobacterial Infections
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia