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NCT00186797 · ClinicalTrials.gov registry record · NA
Purified CD34+ Hematopoietic Stem Cell Transplantation From Alternate Donors for Patients With Severe Aplastic Anemia
A NA study, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- NA
- Development phase
- 28
- Enrollment target
NCT00186797 is a NA study that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 28 participants.
The verdict
NCT00186797, a NA study, has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 28 participants
- Enrollment target
Study Summary
This study is for patients with Severe Aplastic Anemia (SAA). A stem cell transplant from a genetically matched sibling donor can help or cure this disease in 85 to 100 percent of patients. Stem cells are immature blood cells that grow to become red blood cells, white blood cells or platelets. A genetic "match" means a brother or sister has same immune type (HLA type) as the patient. Unfortunately, few patients have a matched sibling donor. The chance of negative outcomes is much higher with other types of donors. This study will test the success of a new approach to stem cell transplant for SAA. Patients in this study will receive drugs and radiation treatment to destroy their diseased bone marrow and to prepare them for stem cell transplant. Bone marrow is the tissue inside the bones where stem cells are made.Stem cells will be harvested from the blood or bone marrow of genetically matched unrelated donors or partially matched family donors. The stem cells will be filtered using a new device that is currently under study. The patients will receive large doses of the filtered stem cells (stem cell graft). Researchers want to find out how the study treatment affects patients, the disease, and the chances for survival.
Interventions
- DRUG Fludarabine, Cyclophosphamide
- PROCEDURE Allogeneic stem cell transplant
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2002-12 |
| Est. Completion | 2007-05 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00186797
The ClinicalTrials.gov registry entry for NCT00186797 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 28 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is St. Jude Children's Research Hospital, which has 410 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Fludarabine, Cyclophosphamide is the first listed.
NCT00186797 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00186797 about?
NCT00186797 is a clinical study titled "Purified CD34+ Hematopoietic Stem Cell Transplantation From Alternate Donors for Patients With Severe Aplastic Anemia". This study is for patients with Severe Aplastic Anemia (SAA). A stem cell transplant from a genetically matched sibling donor can help or cure this disease in 85 to 100 percent of patients. Stem cells are immature blood cells that grow to become red blood cells, white blood cells or platelets. A gen...
What is the current status of trial NCT00186797?
This trial is currently completed. It is a NA study. The enrollment target is 28 participants. The study started on 2002-12. Estimated completion is 2007-05.
What interventions are being tested in trial NCT00186797?
The interventions under investigation include: Fludarabine, Cyclophosphamide (DRUG), Allogeneic stem cell transplant (PROCEDURE).
Who is sponsoring clinical trial NCT00186797?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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