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NCT00090831 · ClinicalTrials.gov registry record
Investigating the Role of Serotonin in Emotional Processing Through the Use of Tryptophan Depletion
A clinical trial, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 91
- Enrollment target
NCT00090831: Completed study, sponsored by National Institute of Mental Health (NIMH).
NCT00090831 is a clinical trial that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 91 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00090831 has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 91 participants
- Enrollment target
Study Summary
This study will examine the role of serotonin function in the brain. Serotonin, one of the brain's natural chemicals, connects with receptors on brain cells to regulate emotion, anxiety, sleep, stress hormones, and other body functions that are disturbed in various mood and anxiety disorders. Also, the research will look at the function of particular brain areas, how they are involved in regulating emotions, and how serotonin is involved in the regulation of their function. The procedures entailed are tryptophan depletion and magnetic resonance imagining (MRI). Also, researchers' understanding of the genetic causes of mood and anxiety disorders will increase through examination of participants' DNA. Adults in good health, ages 20 through 50, may be eligible for this study. Among those not eligible are females who are pregnant or breast feeding, patients with psychiatric or central nervous system disease, and those taking medications that would interfere with study results. At the first visit, patients will be asked about their general mood, degree of nervousness, thinking skills, and behavior. The session will last from 1.5 to 2.0 hours. A blood sample of about 2 tablespoons will be drawn, for DNA study. Participants will undergo the following procedures and tests: * Physical examination. * Test of vital signs, lying and standing. * Electrocardiogram. * Collection of blood for chemistry and hematology. * Urinalysis. * HIV, urine drug, and hepatitis screening. * Psychiatric screening. * (SqrRoot) -HCG pregnancy test, if applicable. At the second visit, patients will receive either tryptophan depletion or placebo, and 5 hours later, the study will begin, to last up to 2 additional hours. Patients will be asked periodically about their emotional state or changes in their well-being. The MRI system will create images of the brain's blood flow and measure glucose metabolism as a measure of brain activity. During the MRI scan, patients will hear knocking or beeping s
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 91 participants |
| Start Date | 2004-08-31 |
| Est. Completion | 2012-09-17 |
What the finished NCT00090831 record still lists
NCT00090831 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 91 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT00090831 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00090831 about?
NCT00090831 is a clinical study titled "Investigating the Role of Serotonin in Emotional Processing Through the Use of Tryptophan Depletion". This study will examine the role of serotonin function in the brain. Serotonin, one of the brain's natural chemicals, connects with receptors on brain cells to regulate emotion, anxiety, sleep, stress hormones, and other body functions that are disturbed in various mood and anxiety disorders. Also, ...
What is the current status of trial NCT00090831?
This trial is currently completed. The enrollment target is 91 participants. The study started on 2004-08-31. Estimated completion is 2012-09-17.
Who is sponsoring clinical trial NCT00090831?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
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