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NCT00082030 · ClinicalTrials.gov registry record
Function of Catecholamines in the Brain During Depression
A clinical trial, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 71
- Enrollment target
NCT00082030 is a clinical trial that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 71 participants.
The verdict
NCT00082030 has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 71 participants
- Enrollment target
Study Summary
This study will explore brain function related to depressive symptoms and will examine DNA for genes that may be involved in depressive disorders, particularly genes that regulate synthesis and metabolism of the brain neurotransmitter catecholamine. It will compare findings in patients with major depressive disorders who are in remission with those in normal, healthy volunteers. Patients with remitted major depressive disorders and healthy normal volunteers between 18 and 60 years of age may be eligible for this study. Candidates are screened with a psychiatric and medical history, physical examination, electrocardiogram, and blood and urine tests. Participants undergo the following tests and procedures in up to eight visits to the NIH Clinical Center: Memory Tasks and Problem Solving and Brain Imaging Subjects are tested with measurements of intelligence or memory ability. They also undergo magnetic resonance imaging (MRI), a test that uses a magnetic field and radio waves to produce images of the brain. For this procedure, the patient lies on a table that is moved into the scanner (a narrow cylinder), and wears earplugs to muffle loud knocking and thumping sounds that occur during the scanning process. The MRI lasts about 60 minutes. Catecholamine Depletion Study For this study, subjects take capsules containing either AMPT (a drug that temporarily reduces brain catecholamine activity) or a placebo (lactose capsules, which do not affect brain catecholamine activity) at 9 a.m., 2 p.m., and 7 p.m. on one visit and return the next day to take additional capsules at 7 a.m. and noon. In addition to the study medication, subjects keep a low-monoamine diet (e.g., no chocolate, cheese, smoked meats, and various other foods that will be enumerated) and do not smoke, drink alcohol, or take in food or drink containing caffeine. After taking all the study capsules, the subjects have positron emission tomography (PET) and functional MRI (fMRI) scans, as follows: * fMRI:
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 71 participants |
| Start Date | 2004-04-19 |
| Est. Completion | 2011-11-18 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00082030
The ClinicalTrials.gov registry entry for NCT00082030 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 71 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute of Mental Health (NIMH), which has 343 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT00082030 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00082030 about?
NCT00082030 is a clinical study titled "Function of Catecholamines in the Brain During Depression". This study will explore brain function related to depressive symptoms and will examine DNA for genes that may be involved in depressive disorders, particularly genes that regulate synthesis and metabolism of the brain neurotransmitter catecholamine. It will compare findings in patients with major de...
What is the current status of trial NCT00082030?
This trial is currently completed. The enrollment target is 71 participants. The study started on 2004-04-19. Estimated completion is 2011-11-18.
Who is sponsoring clinical trial NCT00082030?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
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