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COMPLETED Phase 2

Carboplatin and Gemcitabine Combined With Celecoxib and/or Zileuton in Treating Patients With Advanced Non-Small Cell Lung Cancer

NCT00070486 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Drugs used in chemotherapy, such as carboplatin and gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Celecoxib and zileuton may stop the growth of tumor cells by stopping blood flow to the tumor and may block the enzymes necessary for tumor cell growth. Combining chemotherapy with celecoxib and/or zileuton may kill more tumor cells. PURPOSE: Randomized phase II trial to study the effectiveness of combining celecoxib and/or zileuton with carboplatin and gemcitabine in treating patients who have advanced non-small cell lung cancer.

Conditions Studied

Interventions

  • DRUG carboplatin
  • DRUG gemcitabine hydrochloride
  • DRUG celecoxib
  • DRUG zileuton

Study Locations (20)

California

  • Rebecca and John Moores UCSD Cancer Center — La Jolla
  • Cedars-Sinai Comprehensive Cancer Center at Cedars-Sinai Medical Center — Los Angeles
  • Naval Medical Center - San Diego — San Diego
  • Veterans Affairs Medical Center - San Diego — San Diego
  • UCSF Comprehensive Cancer Center — San Francisco
  • Veterans Affairs Medical Center - San Francisco — San Francisco

Illinois

  • MBCCOP - University of Illinois at Chicago — Chicago
  • Veterans Affairs Medical Center - Chicago (Westside Hospital) — Chicago
  • University of Chicago Cancer Research Center — Chicago
  • Louis A. Weiss Memorial Hospital — Chicago
  • CCOP - Evanston — Evanston

Florida

  • Broward General Medical Center — Fort Lauderdale
  • Memorial Regional Cancer Center at Memorial Regional Hospital — Hollywood
  • CCOP - Mount Sinai Medical Center — Miami Beach
  • Palm Beach Cancer Institute — West Palm Beach

District of Columbia

  • Lombardi Cancer Center at Georgetown University Medical Center — Washington D.C.
  • Walter Reed Army Medical Center — Washington D.C.
  • Veterans Affairs Medical Center - Washington, DC — Washington D.C.

Alabama

  • Northeast Alabama Regional Medical Center — Anniston

Delaware

  • CCOP - Christiana Care Health Services — Newark

Trial Details

FieldValue
Enrollment Target 140 participants
Start Date 2003-12
Est. Completion 2011-05
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00070486

The ClinicalTrials.gov registry entry for NCT00070486 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 140 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance for Clinical Trials in Oncology, which has 147 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Lung Cancer appearing as the primary indexed condition, and to 4 interventions — of which carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00070486 reports 20 study locations spanning 6 distinct geographic areas — top geographies include California, Illinois, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00070486 about?

NCT00070486 is a clinical study titled "Carboplatin and Gemcitabine Combined With Celecoxib and/or Zileuton in Treating Patients With Advanced Non-Small Cell Lung Cancer". RATIONALE: Drugs used in chemotherapy, such as carboplatin and gemcitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Celecoxib and zileuton may stop the growth of tumor cells by stopping blood flow to the tumor and may block the enzymes necessary for tumo...

What is the current status of trial NCT00070486?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 140 participants. The study started on 2003-12. Estimated completion is 2011-05.

What conditions does trial NCT00070486 study?

This clinical trial studies the following conditions: Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00070486?

The interventions under investigation include: carboplatin (DRUG), gemcitabine hydrochloride (DRUG), celecoxib (DRUG), zileuton (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00070486?

This trial is sponsored by Alliance for Clinical Trials in Oncology, which has 147 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00070486 being conducted?

This trial has 20 study locations across Alabama, California, Delaware, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial