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COMPLETED Phase 2

3-AP and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer

NCT00064051 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Drugs used in chemotherapy such as gemcitabine use different ways to stop tumor cells from dividing so they stop growing or die. 3-AP may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth and may help gemcitabine kill more cancer cells by making them more sensitive to the drug. PURPOSE: This phase II trial is studying how well giving gemcitabine together with 3-AP works in treating patients with unresectable or metastatic pancreatic cancer.

Conditions Studied

Interventions

  • DRUG gemcitabine hydrochloride
  • DRUG triapine

Study Locations (7)

England

  • Christie Hospital N.H.S. Trust — Manchester
  • Royal Marsden NHS Foundation Trust - Surrey — Sutton

Illinois

  • University of Chicago Cancer Research Center — Chicago

Indiana

  • Indiana Oncology Hematology Consultants — Indianapolis

Minnesota

  • University of Minnesota Cancer Center — Minneapolis

Tennessee

  • Sarah Cannon Cancer Center at Centennial Medical Center — Nashville

Other

  • Universitair Ziekenhuis Gent — Ghent

Trial Details

FieldValue
Start Date 2003-01
Est. Completion 2008-08
Phase Phase 2

Sponsor

Vion Pharmaceuticals

4 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00064051

The ClinicalTrials.gov registry entry for NCT00064051 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. An enrollment target was not published in the registry record, which is common for early-stage or observational entries. The listed sponsor is Vion Pharmaceuticals, which has 4 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Pancreatic Cancer appearing as the primary indexed condition, and to 2 interventions — of which gemcitabine hydrochloride is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00064051 reports 7 study locations spanning 6 distinct geographic areas — top geographies include England, Illinois, Indiana. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00064051 about?

NCT00064051 is a clinical study titled "3-AP and Gemcitabine in Treating Patients With Unresectable or Metastatic Pancreatic Cancer". RATIONALE: Drugs used in chemotherapy such as gemcitabine use different ways to stop tumor cells from dividing so they stop growing or die. 3-AP may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth and may help gemcitabine kill more cancer cells by making them m...

What is the current status of trial NCT00064051?

This trial is currently completed. It is a Phase 2 study. The study started on 2003-01. Estimated completion is 2008-08.

What conditions does trial NCT00064051 study?

This clinical trial studies the following conditions: Pancreatic Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00064051?

The interventions under investigation include: gemcitabine hydrochloride (DRUG), triapine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00064051?

This trial is sponsored by Vion Pharmaceuticals, which has 4 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00064051 being conducted?

This trial has 7 study locations across Illinois, Indiana, Minnesota, Tennessee, England. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial