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NCT00060736 · ClinicalTrials.gov registry record
The Effects of Estrogen Withdrawal on Mood Symptoms in Women
A clinical trial, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 60
- Enrollment target
NCT00060736: Completed study, sponsored by National Institute of Mental Health (NIMH).
NCT00060736 is a clinical trial that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 60 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00060736 has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 60 participants
- Enrollment target
Study Summary
This study evaluates the effects on mood when stopping estrogen replacement therapy. The purpose of this study is to investigate the effects of estrogen levels on perimenopausal depression. This study will examine short-term withdrawal of estrogen in women whose mood had improved with estrogen therapy. Perimenopause-related mood disorders cause significant distress in a large number of women. Evidence suggests that estradiol may have beneficial effects in women with perimenopausal depression. However, the effect of declining estradiol secretion during perimenopause has not been fully examined. Peri- and post-menopausal women who experience a remission of perimenopause-related depression symptoms while on estrogen therapy and a control group of healthy volunteers on hormone replacement therapy (HRT) will be switched from their current form of HRT to estradiol for a 3-week period; volunteers will also complete symptom ratings to confirm the absence of mood symptoms. Participants will then be randomly assigned to either continue estradiol or take a placebo (an inactive pill) for an additional 3 weeks. Mood ratings will be used to determine response to estradiol withdrawal. ...
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2003-05-05 |
| Est. Completion | 2016-04-27 |
What the finished NCT00060736 record still lists
NCT00060736 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT00060736 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00060736 about?
NCT00060736 is a clinical study titled "The Effects of Estrogen Withdrawal on Mood Symptoms in Women". This study evaluates the effects on mood when stopping estrogen replacement therapy. The purpose of this study is to investigate the effects of estrogen levels on perimenopausal depression. This study will examine short-term withdrawal of estrogen in women whose mood had improved with estrogen ther...
What is the current status of trial NCT00060736?
This trial is currently completed. The enrollment target is 60 participants. The study started on 2003-05-05. Estimated completion is 2016-04-27.
Who is sponsoring clinical trial NCT00060736?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
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