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NCT00055588 · ClinicalTrials.gov registry record · Phase 1
Nervous System Function in Normal Volunteers During Cycling Training
A Phase 1 study, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- Phase 1
- Development phase
- 60
- Enrollment target
NCT00055588: Completed Phase 1 study, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT00055588 is a Phase 1 study that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 60 participants, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00055588, a Phase 1 study, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 60 participants
- Enrollment target
Study Summary
This study will identify changes that occur in the nervous system of healthy normal volunteers while they are learning a cycling task. Healthy subjects 18 years of age and older who can cycle for 16 minutes may be eligible for this study. Candidates will be screened with a brief medical history and physical examination. Participants will be assigned to one of three groups: * Complex training: Cycling for 16 minutes at a constant speed of 60 rpm with frequent changes in pedal resistance. * Simple training: Cycling for 16 minutes at a constant speed of 60 rpm with no changes in pedal resistance. * No training: Remaining seated on the bike for 16 minutes performing no exercise. Participants will cycle for 16 minutes for the training task, plus 4 minutes before and after the training. Reflexes will be measured with nerve conduction studies and somatosensory evoked potential (SSEP) recordings before and after training. Nerve conduction studies measure the speed with which nerves conduct electrical impulses and the strength of the connection between the nerve and the muscle. For these studies, a probe is placed on the skin over the calf muscles and the knee to deliver a small electrical stimulus, and wires are taped to the skin to record the impulses. SSEP recordings, which measure of the excitability of the brain to sensory stimuli, are collected from electrodes placed on the scalp. After the training period, multiple train stimulation (MTS) is applied for 10 minutes. For MTS, weak electrical currents are delivered for 10 seconds every 10 seconds. These stimuli produce a buzzing sensation without pain, discomfort, or muscle twitching. The MTS is followed by another 4 minutes of cycling. Participants also undergo transcranial magnetic stimulation (TMS). For this procedure, an insulated wire coil is held over the scalp. A brief electrical current is passed through the coil, creating a magnetic pulse that travels through the scalp and skull and causes small electrical
Interventions
- PROCEDURE Locomotor training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2003-03-04 |
| Est. Completion | 2008-05-20 |
| Phase | Phase 1 |
What the finished NCT00055588 record still lists
NCT00055588 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, roughly in line with the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target.
The record links to 0 conditions, and to 1 intervention - of which Locomotor training is the first listed.
NCT00055588 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00055588 about?
NCT00055588 is a clinical study titled "Nervous System Function in Normal Volunteers During Cycling Training". This study will identify changes that occur in the nervous system of healthy normal volunteers while they are learning a cycling task. Healthy subjects 18 years of age and older who can cycle for 16 minutes may be eligible for this study. Candidates will be screened with a brief medical history and...
What is the current status of trial NCT00055588?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 60 participants. The study started on 2003-03-04. Estimated completion is 2008-05-20.
What interventions are being tested in trial NCT00055588?
The interventions under investigation include: Locomotor training (PROCEDURE).
Who is sponsoring clinical trial NCT00055588?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00055588's enrollment target sits among peer trials
60 831st of 2000 higher than 1,106 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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