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NCT00044096 · ClinicalTrials.gov registry record
Psychopharmacology of Fear-Potentiated Startle in Humans
A clinical trial, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 225
- Enrollment target
NCT00044096: Completed study, sponsored by National Institute of Mental Health (NIMH).
NCT00044096 is a clinical trial that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 225 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00044096 has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 225 participants
- Enrollment target
Study Summary
The purpose of this study is to understand the effects of the drug alprazolam (Xanax ) on anxiety. To understand the effect of anxiety-relieving drugs on fear and anxiety, researchers often have participants anticipate unpleasant stimuli. Anticipating unpleasant stimuli increases or potentiates a simple reflex called the startle reflex. The so-called fear-potentiated startle reflex (FPS) effect may be blocked or reduced by anxiety-relieving drugs. Evidence suggests that the FPS can be mediated by two mechanisms that regulate the phasic- and sustained enhancement of startle. This study will elicit phasic and sustained FPS in participants by having them anticipate moderately painful stimuli that are administered predictably and unpredictably. The main goal of this study is to assess the affect of alprazolam on the phasic and sustained enhancement of startle. This study comprises two pilot experiments and a main study. Participants in the study will be screened with a psychiatric history, physical examination, electrocardiogram (EKG), and blood and urine tests. Participants will four testing sessions separated by 5 to 10 days. At each session, participants will be given one of two doses of alprazolam, diphenhydramine, or placebo (an inactive pill). Questionnaires and other tests will be performed.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 225 participants |
| Start Date | 2002-08-15 |
| Est. Completion | 2013-09-17 |
What the finished NCT00044096 record still lists
NCT00044096 is an observational study that tracks outcomes without assigning an intervention. The registered 225 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT00044096 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00044096 about?
NCT00044096 is a clinical study titled "Psychopharmacology of Fear-Potentiated Startle in Humans". The purpose of this study is to understand the effects of the drug alprazolam (Xanax ) on anxiety. To understand the effect of anxiety-relieving drugs on fear and anxiety, researchers often have participants anticipate unpleasant stimuli. Anticipating unpleasant stimuli increases or potentiates a s...
What is the current status of trial NCT00044096?
This trial is currently completed. The enrollment target is 225 participants. The study started on 2002-08-15. Estimated completion is 2013-09-17.
Who is sponsoring clinical trial NCT00044096?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
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