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COMPLETED Phase 3

Paclitaxel With or Without Bevacizumab in Treating Patients With Locally Recurrent or Metastatic Breast Cancer

NCT00028990 · View on ClinicalTrials.gov ↗

Study Summary

RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies, such as bevacizumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or deliver cancer-killing substances to them. It is not yet known whether paclitaxel works better with or without bevacizumab in treating breast cancer. PURPOSE: This randomized phase III trial is to see if paclitaxel works better with or without bevacizumab in treating patients who have locally recurrent or metastatic breast cancer.

Conditions Studied

Interventions

  • DRUG Paclitaxel
  • DRUG bevacizumab

Study Locations (20)

Minnesota

  • CCOP - Duluth — Duluth
  • Mayo Clinic Cancer Center — Rochester
  • CentraCare Health Plaza — Saint Cloud
  • CCOP - Metro-Minnesota — Saint Louis Park

Iowa

  • CCOP - Cedar Rapids Oncology Project — Cedar Rapids
  • CCOP - Iowa Oncology Research Association — Des Moines
  • Siouxland Hematology-Oncology — Sioux City

North Dakota

  • Medcenter One Health System — Bismarck
  • CCOP - Merit Care Hospital — Fargo
  • Altru Cancer Center — Grand Forks

Illinois

  • CCOP - Illinois Oncology Research Association — Peoria
  • CCOP - Carle Cancer Center — Urbana

Alabama

  • MBCCOP - Gulf Coast — Mobile

Arizona

  • CCOP - Mayo Clinic Scottsdale Oncology Program — Scottsdale

Florida

  • Mayo Clinic - Jacksonville — Jacksonville

Georgia

  • CCOP - Atlanta Regional — Atlanta

Trial Details

FieldValue
Enrollment Target 722 participants
Start Date 2002-01-29
Est. Completion 2009-05
Phase Phase 3

Sponsor

Eastern Cooperative Oncology Group

30 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00028990

The ClinicalTrials.gov registry entry for NCT00028990 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 722 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eastern Cooperative Oncology Group, which has 30 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Breast Cancer appearing as the primary indexed condition, and to 2 interventions — of which Paclitaxel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00028990 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Minnesota, Iowa, North Dakota. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00028990 about?

NCT00028990 is a clinical study titled "Paclitaxel With or Without Bevacizumab in Treating Patients With Locally Recurrent or Metastatic Breast Cancer". RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop tumor cells from dividing so they stop growing or die. Monoclonal antibodies, such as bevacizumab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others fi...

What is the current status of trial NCT00028990?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 722 participants. The study started on 2002-01-29. Estimated completion is 2009-05.

What conditions does trial NCT00028990 study?

This clinical trial studies the following conditions: Breast Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00028990?

The interventions under investigation include: Paclitaxel (DRUG), bevacizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00028990?

This trial is sponsored by Eastern Cooperative Oncology Group, which has 30 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00028990 being conducted?

This trial has 20 study locations across Alabama, Arizona, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial