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NCT00025974 · ClinicalTrials.gov registry record
Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder
A clinical trial, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 230
- Enrollment target
NCT00025974 is a clinical trial that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 230 participants.
The verdict
NCT00025974 has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 230 participants
- Enrollment target
Study Summary
The purpose of this study is to examine how certain brain chemicals work in patients with Panic Disorder (PD) and Post-Traumatic Stress Disorder (PTSD) with and without major depressive disorder (MDD). Brain chemicals that regulate emotion, anxiety, sleep, stress hormones, and other body functions bind to serotonin (5-HT1A) and benzodiazepine (BZD) receptors. Evidence suggests that 5-HT1A and BZD receptor function is abnormal in patients with PD, PTSD, and depression. This study will use positron emission tomography (PET) scans to examine BZD and 5-HT1A receptor binding potential in patients with PD and patients with PTSD with and without co-morbid MDD, as well as in healthy volunteers. This study will also determine the effects of the stress hormone cortisol on 5-HT1A and BZD receptors. The current emotional state and psychiatric, medical, and family history of potential participants will be evaluated during an initial telephone interview. After entering the study, participants will be asked questions about general mood, degree of nervousness, and behavior. A physical examination, an electrocardiogram (EKG), and tests of intelligence and cognition will be given. Urine, blood, and saliva samples will be taken. Women will be given pregnancy tests and tests to determine menstrual phase and time of ovulation. All volunteers will undergo magnetic resonance imaging (MRI) and PET scans of the brain. ...
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 230 participants |
| Start Date | 2001-10-31 |
| Est. Completion | 2008-07-21 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00025974
The ClinicalTrials.gov registry entry for NCT00025974 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 230 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute of Mental Health (NIMH), which has 343 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT00025974 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00025974 about?
NCT00025974 is a clinical study titled "Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder". The purpose of this study is to examine how certain brain chemicals work in patients with Panic Disorder (PD) and Post-Traumatic Stress Disorder (PTSD) with and without major depressive disorder (MDD). Brain chemicals that regulate emotion, anxiety, sleep, stress hormones, and other body functions ...
What is the current status of trial NCT00025974?
This trial is currently completed. The enrollment target is 230 participants. The study started on 2001-10-31. Estimated completion is 2008-07-21.
Who is sponsoring clinical trial NCT00025974?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
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