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NCT00011258 · ClinicalTrials.gov registry record
Paraoxonase and LDL Oxidation in Carotid Artery Disease
A clinical trial of Carotid Stenosis, sponsored by US Department of Veterans Affairs.
- Completed
- Registry status
- 1,000
- Enrollment target
- 1
- Study location
NCT00011258: Completed study of Carotid Stenosis, sponsored by US Department of Veterans Affairs.
NCT00011258 is a study of Carotid Stenosis that has completed, run by US Department of Veterans Affairs. The registered enrollment target is 1,000 participants, above the 509-participant average among 11 other Carotid Stenosis trials with a reported enrollment target (96% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00011258, a study of Carotid Stenosis, has completed, sponsored by US Department of Veterans Affairs.
- COMPLETED
- Registry status
- 1,000 participants
- Enrollment target
- 1
- Study location
Study Summary
Atherosclerosis of the carotid arteries is a common cause of stroke. The prevalence and progression of carotid atherosclerosis are believed to be influenced by genetically inherited variations in lipoprotein metabolism. This study investigates the specific role of paraoxonase, an enzyme thought to detoxify atherogenic oxidized low-density lipoprotein. This study compares veterans who have significant carotid atherosclerosis on ultrasound examination with controls without carotid atherosclerosis. Both paraoxonase activity and genotype will be determined and compared between groups. The results may eventually make it possible to screen for a paraoxonase allele that confers high risk of atherosclerosis, and to diminish the risk by early treatment.
Conditions Studied
Interventions
- DRUG Paraoxonase
Study Locations (1)
Washington
- VA Puget Sound Health Care System - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 1997-03 |
| Est. Completion | 2003-09 |
What the finished NCT00011258 record still lists
NCT00011258 is an observational study that tracks outcomes without assigning an intervention. Its 1,000 participants enrollment target places it among the larger protocols in the corpus, above the 509-participant average among 11 other Carotid Stenosis trials with a reported enrollment target (96% higher).
The record links to 1 condition, with Carotid Stenosis appearing as the primary indexed condition, and to 1 intervention - of which Paraoxonase is the first listed.
NCT00011258 reports a single indexed study location in Washington.
Frequently Asked Questions
What is clinical trial NCT00011258 about?
NCT00011258 is a clinical study titled "Paraoxonase and LDL Oxidation in Carotid Artery Disease". Atherosclerosis of the carotid arteries is a common cause of stroke. The prevalence and progression of carotid atherosclerosis are believed to be influenced by genetically inherited variations in lipoprotein metabolism. This study investigates the specific role of paraoxonase, an enzyme thought to d...
What is the current status of trial NCT00011258?
This trial is currently completed. The enrollment target is 1,000 participants. The study started on 1997-03. Estimated completion is 2003-09.
What conditions does trial NCT00011258 study?
This clinical trial studies the following conditions: Carotid Stenosis.
What interventions are being tested in trial NCT00011258?
The interventions under investigation include: Paraoxonase (DRUG).
Who is sponsoring clinical trial NCT00011258?
This trial is sponsored by US Department of Veterans Affairs, which has 632 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00011258 being conducted?
This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Carotid Stenosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00011258's enrollment target sits among peer trials
1,000 2nd of 11 the highest of 11 other Carotid Stenosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Carotid Stenosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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