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NCT00011258 · ClinicalTrials.gov registry record
Paraoxonase and LDL Oxidation in Carotid Artery Disease
A clinical trial of Carotid Stenosis, sponsored by US Department of Veterans Affairs.
- Completed
- Registry status
- 1,000
- Enrollment target
- 1
- Study location
NCT00011258 is a study of Carotid Stenosis that has completed, run by US Department of Veterans Affairs. The registered enrollment target is 1,000 participants, above the 509-participant average among 11 other Carotid Stenosis trials with a reported enrollment target (96% higher). The trial reports 1 study location across 1 state.
The verdict
NCT00011258, a study of Carotid Stenosis, has completed, sponsored by US Department of Veterans Affairs.
- COMPLETED
- Registry status
- 1,000 participants
- Enrollment target
- 1
- Study location
Study Summary
Atherosclerosis of the carotid arteries is a common cause of stroke. The prevalence and progression of carotid atherosclerosis are believed to be influenced by genetically inherited variations in lipoprotein metabolism. This study investigates the specific role of paraoxonase, an enzyme thought to detoxify atherogenic oxidized low-density lipoprotein. This study compares veterans who have significant carotid atherosclerosis on ultrasound examination with controls without carotid atherosclerosis. Both paraoxonase activity and genotype will be determined and compared between groups. The results may eventually make it possible to screen for a paraoxonase allele that confers high risk of atherosclerosis, and to diminish the risk by early treatment.
Conditions Studied
Interventions
- DRUG Paraoxonase
Study Locations (1)
Washington
- VA Puget Sound Health Care System - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 1997-03 |
| Est. Completion | 2003-09 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00011258
The ClinicalTrials.gov registry entry for NCT00011258 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 1,000 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 509-participant average among 11 other Carotid Stenosis trials with a reported enrollment target (96% higher). The listed sponsor is US Department of Veterans Affairs, which has 632 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Carotid Stenosis appearing as the primary indexed condition, and to 1 intervention - of which Paraoxonase is the first listed.
NCT00011258 reports 1 study location spanning 1 distinct geographic area - top geographies include Washington.
Frequently Asked Questions
What is clinical trial NCT00011258 about?
NCT00011258 is a clinical study titled "Paraoxonase and LDL Oxidation in Carotid Artery Disease". Atherosclerosis of the carotid arteries is a common cause of stroke. The prevalence and progression of carotid atherosclerosis are believed to be influenced by genetically inherited variations in lipoprotein metabolism. This study investigates the specific role of paraoxonase, an enzyme thought to d...
What is the current status of trial NCT00011258?
This trial is currently completed. The enrollment target is 1,000 participants. The study started on 1997-03. Estimated completion is 2003-09.
What conditions does trial NCT00011258 study?
This clinical trial studies the following conditions: Carotid Stenosis.
What interventions are being tested in trial NCT00011258?
The interventions under investigation include: Paraoxonase (DRUG).
Who is sponsoring clinical trial NCT00011258?
This trial is sponsored by US Department of Veterans Affairs, which has 632 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00011258 being conducted?
This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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