Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00004467 · ClinicalTrials.gov registry record · Phase 3
Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen
A Phase 3 study of Acute Liver Failure, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
- Completed
- Registry status
- Phase 3
- Development phase
- 173
- Enrollment target
- 20
- Study locations
NCT00004467: Completed Phase 3 study of Acute Liver Failure, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
NCT00004467 is a Phase 3 study of Acute Liver Failure that has completed, run by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The registered enrollment target is 173 participants, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (78% lower). The trial reports 20 study locations across 14 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00004467, a Phase 3 study of Acute Liver Failure, has completed, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 173 participants
- Enrollment target
- 20
- Study locations
Study Summary
OBJECTIVES: I. Determine the safety and efficacy of a short course (72 hours) of intravenous acetylcysteine in patients with acute liver failure for whom no antidote or specific treatment is available.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG N-acetylcysteine (NAC)
Study Locations (20)
California
- University of California Los Angeles - Los Angeles
- University of California Davis - Sacramento
- University of California San Diego - San Diego
- University of California San Francisco - San Francisco
Pennsylvania
- University of Pennsylvania - Philadelphia
- Albert Einstein Medical Center - Philadelphia
- University of Pittsburgh Medical Center - Pittsburgh
New York
- Mount Sinai Medical Center, NY - New York
- New York Presbyterian Hospital - New York
Alabama
- University of Alabama at Birmingham - Birmingham
Arizona
- Mayo Clinic - Scottsdale
Florida
- Mayo Clinic - Jacksonville
Illinois
- Northwestern University Medical School - Chicago
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 173 participants |
| Start Date | 1998-06 |
| Est. Completion | 2006-11 |
| Phase | Phase 3 |
What the finished NCT00004467 record still lists
NCT00004467 is an interventional study that assigns participants to a tested intervention. The registered 173 participants enrollment target is mid-sized for trials with a published cap, below the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (78% lower).
The record links to 1 condition, with Acute Liver Failure appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT00004467 names 20 study sites across 14 states, led by California, Pennsylvania, New York.
Frequently Asked Questions
What is clinical trial NCT00004467 about?
NCT00004467 is a clinical study titled "Randomized Study of Acetylcysteine in Patients With Acute Liver Failure Not Caused by Acetaminophen". OBJECTIVES: I. Determine the safety and efficacy of a short course (72 hours) of intravenous acetylcysteine in patients with acute liver failure for whom no antidote or specific treatment is available.
What is the current status of trial NCT00004467?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 173 participants. The study started on 1998-06. Estimated completion is 2006-11.
What conditions does trial NCT00004467 study?
This clinical trial studies the following conditions: Acute Liver Failure.
What interventions are being tested in trial NCT00004467?
The interventions under investigation include: Placebo (DRUG), N-acetylcysteine (NAC) (DRUG).
Who is sponsoring clinical trial NCT00004467?
This trial is sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which has 490 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00004467 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Acute Liver Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00004467's enrollment target sits among peer trials
173 1445th of 2000 higher than 553 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT05568719 · 173 participants · Phase 3
Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B Respectively
- NCT07070115 · 173 participants · NA
Evaluating Clinical Hiatal Hernia Outcomes Using OviTex®
- NCT07150832 · 173 participants · NA
Efficacy of the I-CARE Digital Health Intervention
- NCT01000259 · 174 participants
Study of Tumor Tissue Samples From Patients Who Have Undergone Surgery for Advanced Stage III or Stage IV Ovarian Epithelial Cancer
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia