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NCT00001639 · ClinicalTrials.gov registry record
Evaluation of Patients With Unresolved Chromosome Abnormalities
A clinical trial of Microcephaly and Abnormalities, sponsored by National Human Genome Research Institute (NHGRI).
- Completed
- Registry status
- 263
- Enrollment target
- 1
- Study location
NCT00001639 is a study of Microcephaly and Abnormalities that has completed, run by National Human Genome Research Institute (NHGRI). The registered enrollment target is 263 participants, above the 218-participant average among 3 other Microcephaly trials with a reported enrollment target (21% higher). The trial reports 1 study location across 1 state.
The verdict
NCT00001639, a study of Microcephaly and Abnormalities, has completed, sponsored by National Human Genome Research Institute (NHGRI).
- COMPLETED
- Registry status
- 263 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this research is to study a new way to test for chromosome abnormalities. Chromosomes are strands of DNA (the genetic material in the cell nucleus) that are made up of genes-the units of heredity. Chromosome abnormalities are usually investigated by staining the chromosomes with a dye (Giemsa stain) and examining them under a microscope. This method can detect many duplications and deletions of pieces of chromosomes and is very accurate in diagnosing certain abnormalities. It is not useful, however, for identifying very small abnormalities. This study will evaluate the accuracy of a test method using 24 different dyes for finding small chromosome abnormalities. Children and adults with various chromosome abnormalities may be eligible for this study, including, for example, people with developmental delay or mental retardation, abnormal growth features or growth retardation, and certain behavioral disorders. Participants will be evaluated in the clinic over a 1- to 3-day period, depending on their symptoms. All participants will be examined by a genetics specialist and will have a physical examination and possibly X-rays, computerized tomography (CT) scans, magnetic resonance imaging (MRI), ultrasound studies and medical photography. Blood will be drawn for chromosome testing-about 3 tablespoons from adults and 1 to 3 teaspoons from children. When the test results are available, participants will return to the clinic for follow-up evaluation and review of the test findings. The genetic and medical evaluations, along with their implications, will be discussed.
Conditions Studied
Study Locations (1)
Maryland
- National Human Genome Research Institute (NHGRI) - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 263 participants |
| Start Date | 1996-12 |
| Est. Completion | 2000-10 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00001639
The ClinicalTrials.gov registry entry for NCT00001639 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 263 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 218-participant average among 3 other Microcephaly trials with a reported enrollment target (21% higher). The listed sponsor is National Human Genome Research Institute (NHGRI), which has 185 total studies on file at ClinicalTrials.gov.
The record links to 4 conditions, with Microcephaly appearing as the primary indexed condition, and to 0 interventions.
NCT00001639 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT00001639 about?
NCT00001639 is a clinical study titled "Evaluation of Patients With Unresolved Chromosome Abnormalities". The purpose of this research is to study a new way to test for chromosome abnormalities. Chromosomes are strands of DNA (the genetic material in the cell nucleus) that are made up of genes-the units of heredity. Chromosome abnormalities are usually investigated by staining the chromosomes with a dye...
What is the current status of trial NCT00001639?
This trial is currently completed. The enrollment target is 263 participants. The study started on 1996-12. Estimated completion is 2000-10.
What conditions does trial NCT00001639 study?
This clinical trial studies the following conditions: Microcephaly, Abnormalities, Mental Retardation, Failure to Thrive.
Who is sponsoring clinical trial NCT00001639?
This trial is sponsored by National Human Genome Research Institute (NHGRI), which has 185 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00001639 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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