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NCT00001253 · ClinicalTrials.gov registry record · Phase 2
The Effects of Estrogen on Cognition in Girls With Turner Syndrome
A Phase 2 study, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
- Completed
- Registry status
- Phase 2
- Development phase
- 950
- Enrollment target
NCT00001253 is a Phase 2 study that has completed, run by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The registered enrollment target is 950 participants.
The verdict
NCT00001253, a Phase 2 study, has completed, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 950 participants
- Enrollment target
Study Summary
The development of the brain in females is a result of a combination of factors. During puberty estrogen plays a role in influencing brain development. Cultural and environmental factors also play a role in the development of the brain. Female patients with Turner syndrome lack the ability to produce estrogen due to undeveloped ovaries. Therefore, Turner syndrome is the perfect condition to study how estrogen (or the lack of estrogen) influences a person's behavior and thinking. This study will compare cognitive differences (visual motor skills, visual-spatial, psychosocial behavior, and visual memory) of patients with Turner syndrome to normal patient controls. Researchers will use the Weschler Intelligence Scale for Children-Revised (WISC-R) along with other tests and scales to measure different aspects of the patient's cognitive ability. In addition the study will review patients with Turner syndrome who previously received estrogen replacement as infants and children in a related research study. Researchers hope to demonstrate that estrogen replacement will improve cognition and behavior in girls with Turner syndrome.
Interventions
- BEHAVIORAL cognitive tests and scales
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 950 participants |
| Start Date | 1990-05 |
| Est. Completion | 2004-03 |
| Phase | Phase 2 |
Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)305 total trials
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00001253
The ClinicalTrials.gov registry entry for NCT00001253 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 950 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which has 305 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which cognitive tests and scales is the first listed.
NCT00001253 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00001253 about?
NCT00001253 is a clinical study titled "The Effects of Estrogen on Cognition in Girls With Turner Syndrome". The development of the brain in females is a result of a combination of factors. During puberty estrogen plays a role in influencing brain development. Cultural and environmental factors also play a role in the development of the brain. Female patients with Turner syndrome lack the ability to produ...
What is the current status of trial NCT00001253?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 950 participants. The study started on 1990-05. Estimated completion is 2004-03.
What interventions are being tested in trial NCT00001253?
The interventions under investigation include: cognitive tests and scales (BEHAVIORAL).
Who is sponsoring clinical trial NCT00001253?
This trial is sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which has 305 total clinical trials registered on ClinicalTrials.gov.
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