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NCT00001253 · ClinicalTrials.gov registry record · Phase 2
The Effects of Estrogen on Cognition in Girls With Turner Syndrome
A Phase 2 study, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
- Completed
- Registry status
- Phase 2
- Development phase
- 950
- Enrollment target
NCT00001253: Completed Phase 2 study, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
NCT00001253 is a Phase 2 study that has completed, run by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The registered enrollment target is 950 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (614% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00001253, a Phase 2 study, has completed, sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 950 participants
- Enrollment target
Study Summary
The development of the brain in females is a result of a combination of factors. During puberty estrogen plays a role in influencing brain development. Cultural and environmental factors also play a role in the development of the brain. Female patients with Turner syndrome lack the ability to produce estrogen due to undeveloped ovaries. Therefore, Turner syndrome is the perfect condition to study how estrogen (or the lack of estrogen) influences a person's behavior and thinking. This study will compare cognitive differences (visual motor skills, visual-spatial, psychosocial behavior, and visual memory) of patients with Turner syndrome to normal patient controls. Researchers will use the Weschler Intelligence Scale for Children-Revised (WISC-R) along with other tests and scales to measure different aspects of the patient's cognitive ability. In addition the study will review patients with Turner syndrome who previously received estrogen replacement as infants and children in a related research study. Researchers hope to demonstrate that estrogen replacement will improve cognition and behavior in girls with Turner syndrome.
Interventions
- BEHAVIORAL cognitive tests and scales
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 950 participants |
| Start Date | 1990-05 |
| Est. Completion | 2004-03 |
| Phase | Phase 2 |
Sponsor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)305 total trials
What the finished NCT00001253 record still lists
NCT00001253 is an interventional study that assigns participants to a tested intervention. The registered 950 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (614% higher).
The record links to 0 conditions, and to 1 intervention - of which cognitive tests and scales is the first listed.
NCT00001253 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00001253 about?
NCT00001253 is a clinical study titled "The Effects of Estrogen on Cognition in Girls With Turner Syndrome". The development of the brain in females is a result of a combination of factors. During puberty estrogen plays a role in influencing brain development. Cultural and environmental factors also play a role in the development of the brain. Female patients with Turner syndrome lack the ability to produ...
What is the current status of trial NCT00001253?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 950 participants. The study started on 1990-05. Estimated completion is 2004-03.
What interventions are being tested in trial NCT00001253?
The interventions under investigation include: cognitive tests and scales (BEHAVIORAL).
Who is sponsoring clinical trial NCT00001253?
This trial is sponsored by Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which has 305 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00001253's enrollment target sits among peer trials
950 29th of 2000 higher than 1,972 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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