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NCT00000706 · ClinicalTrials.gov registry record · NA

Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine

A NA study of HIV Infections, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

Completed
Registry status
NA
Development phase
12
Enrollment target
1
Study location

NCT00000706 is a NA study of HIV Infections that has completed, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 12 participants, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT00000706, a NA study of HIV Infections, has completed, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).

COMPLETED
Registry status
NA
Development phase
12 participants
Enrollment target
1
Study location

Study Summary

Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and eliminated through the kidneys in HIV infected patients. Part II studies the effect of probenecid and quinine on the same aspects. Because AZT leaves the bloodstream quickly, patients must take the drug frequently to keep adequate amounts in their bodies. Probenecid and quinine may slow down the rate at which AZT leaves the body. Therefore, taking these drugs along with AZT may reduce the amount of AZT needed for treatment.

Conditions Studied

HIV Infections

Interventions

  • DRUG Zidovudine
  • DRUG Probenecid
  • DRUG Quinine sulfate

Study Locations (1)

Maryland

  • Johns Hopkins Hosp - Baltimore

Trial Details

FieldValue
Enrollment Target 12 participants
Est. Completion 1988-12
Phase NA

Sponsor

National Institute of Allergy and Infectious Diseases (NIAID)

2,006 total trials

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What the Registry Record Tells You About NCT00000706

The ClinicalTrials.gov registry entry for NCT00000706 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 12 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 446-participant average among 542 other HIV Infections trials with a reported enrollment target (97% lower). The listed sponsor is National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with HIV Infections appearing as the primary indexed condition, and to 3 interventions - of which Zidovudine is the first listed.

NCT00000706 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.

Frequently Asked Questions

What is clinical trial NCT00000706 about?

NCT00000706 is a clinical study titled "Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine". Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and eliminated through the kidneys in HIV infected patients. Part II studies the effect of probenecid and quinine on the same aspects. Because AZT leaves the bloodstream quickly, patients must take the drug frequently ...

What is the current status of trial NCT00000706?

This trial is currently completed. It is a NA study. The enrollment target is 12 participants. Estimated completion is 1988-12.

What conditions does trial NCT00000706 study?

This clinical trial studies the following conditions: HIV Infections.

What interventions are being tested in trial NCT00000706?

The interventions under investigation include: Zidovudine (DRUG), Probenecid (DRUG), Quinine sulfate (DRUG).

Who is sponsoring clinical trial NCT00000706?

This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00000706 being conducted?

This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.