Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 6 recruiting now official registry

Unresectable Hepatocellular Carcinoma clinical trials

Every US clinical trial registered for Unresectable Hepatocellular Carcinoma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

13 US clinical trials · 6 currently recruiting

The research picture

Unresectable Hepatocellular Carcinoma has 13 registered US clinical trials, 6 of them open to new participants right now — about 46% of the total.

6
recruiting participants now
46%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: Mayo Clinic

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 300 participants

An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery

Bayer

NCT06117891

RECRUITING Phase 2 122 participants

Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

Academic and Community Cancer Research United

NCT05168163

RECRUITING Phase 1 85 participants

Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer

Mayo Clinic

NCT03942328

RECRUITING Phase 2 30 participants

Regorafenib and Yttrium-90 Radioembolization for Unresectable Hepatocellular Carcinoma

University of Miami

NCT06902246

RECRUITING Phase 1 20 participants

Atezolizumab+Bevacizumab+SBRT in Unresectable HCC

Massachusetts General Hospital

NCT05096715

RECRUITING Phase 2 19 participants

Lenvatinib for the Treatment of Recurrent Hepatocellular Carcinoma After Liver Transplant

Emory University

NCT05103904

ACTIVE NOT RECRUITING Phase 3 186 participants

Radiation Therapy With Protons or Photons in Treating Patients With Liver Cancer

NRG Oncology

NCT03186898

ACTIVE NOT RECRUITING NA 100 participants

Selective Internal Radiation Therapy (SIRT) Using SIR-Spheres® Y-90 Resin Microspheres on DoR & ORR in Unresectable Hepatocellular Carcinoma Patients

Sirtex Medical

NCT04736121

ACTIVE NOT RECRUITING Phase 2 50 participants

A Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma

Howard S Hochster

NCT04829383

ACTIVE NOT RECRUITING NA 42 participants

Radioembolization for HCC Patients With Personalized Yttrium-90 Dosimetry for Curative Intent (RAPY90D)

M.D. Anderson Cancer Center

NCT03896646

ACTIVE NOT RECRUITING Phase 1 30 participants

Delivering a Diuretic Into the Liver Artery Followed by Plugging up the Artery to Starve Out Liver Cancer Cells

Memorial Sloan Kettering Cancer Center

NCT03107416

ACTIVE NOT RECRUITING Phase 1 25 participants

Durvalumab and Tremelimumab After Radioembolization for the Treatment of Unresectable, Locally Advanced Liver Cancer

City of Hope Medical Center

NCT04605731

COMPLETED Phase 2 29 participants

68Ga PSMA PET Imaging for the Treatment of Advanced Liver Cancer

Mayo Clinic

NCT05176223

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 5
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Unresectable Hepatocellular Carcinoma Trial Landscape

ClinicalTrials.gov lists 13 US studies indexed under Unresectable Hepatocellular Carcinoma, and 6 of those are currently open to recruitment — roughly 46% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Unresectable Hepatocellular Carcinoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 9 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Unresectable Hepatocellular Carcinoma is led by Mayo Clinic with 2 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 13 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Unresectable Hepatocellular Carcinoma?

PlainTrial tracks 13 US clinical trials for Unresectable Hepatocellular Carcinoma, of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Unresectable Hepatocellular Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →