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A Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma
NCT04829383 · View on ClinicalTrials.gov ↗
Study Summary
This will be a nonrandomized, single arm feasibility study with the primary goal of evaluating the safety profile of the combination of atezolizumab and bevacizumab in patients with advanced/metastatic HCC with Child-Pugh B7 and B8 liver disease who have received no prior systemic therapy.
Conditions Studied
Interventions
- DRUG Bevacizumab
- DRUG Atezolizumab
Study Locations (7)
Illinois
- University of Illinois Cancer Center — Chicago
Indiana
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center — Indianapolis
Nebraska
- University of Nebraska Medical Center — Omaha
New Jersey
- Rutgers Cancer Institute of New Jersey — New Brunswick
New York
- New York University Clinical Cancer Center — New York
Texas
- DHR Health Institute for Research and Development — Edinburg
Wisconsin
- Univeristy of Wisconsin — Madison
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2021-03-22 |
| Est. Completion | 2025-10 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04829383
The ClinicalTrials.gov registry entry for NCT04829383 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 50 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Howard S Hochster, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Unresectable Hepatocellular Carcinoma appearing as the primary indexed condition, and to 2 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04829383 reports 7 study locations spanning 7 distinct geographic areas — top geographies include Illinois, Indiana, Nebraska. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04829383 about?
NCT04829383 is a clinical study titled "A Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma". This will be a nonrandomized, single arm feasibility study with the primary goal of evaluating the safety profile of the combination of atezolizumab and bevacizumab in patients with advanced/metastatic HCC with Child-Pugh B7 and B8 liver disease who have received no prior systemic therapy.
What is the current status of trial NCT04829383?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2021-03-22. Estimated completion is 2025-10.
What conditions does trial NCT04829383 study?
This clinical trial studies the following conditions: Unresectable Hepatocellular Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04829383?
The interventions under investigation include: Bevacizumab (DRUG), Atezolizumab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04829383?
This trial is sponsored by Howard S Hochster, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04829383 being conducted?
This trial has 7 study locations across Illinois, Indiana, Nebraska, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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