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NCT06363877 · ClinicalTrials.gov registry record · Phase 3
Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections
A Phase 3 study of Surgical Site Infection, sponsored by Loma Linda University.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 1,100
- Enrollment target
- 1
- Study location
NCT06363877: Recruiting Phase 3 study of Surgical Site Infection, sponsored by Loma Linda University.
NCT06363877 is a Phase 3 study of Surgical Site Infection that is actively recruiting participants, run by Loma Linda University. The registered enrollment target is 1,100 participants, above the 524-participant average among 25 other Surgical Site Infection trials with a reported enrollment target (110% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06363877, a Phase 3 study of Surgical Site Infection, is actively recruiting participants, sponsored by Loma Linda University.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 1,100 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 years old undergoing emergency laparotomies with Centers for Disease Control (CDC) class 2 and 3 wounds.
Primary Outcome
Subjects in each study arm will be assessed for presence of surgical site infection using a composite measurement based on the CDC/NHSN Guidelines for Surgical Site Infection (SSI) Event (January 2024). The presence of one or more of the following will constitute a surgical site infection: 1. purulent drainage from the superficial incision, deep incision or the drain in an organ/space 2. organism(s) identified from an aseptically-obtained specimen from the superficial incision, subcutaneous ti
Conditions Studied
Interventions
- DRUG Povidone-Iodine
- DRUG Normal Saline
Study Locations (1)
California
- Loma Linda University Health - Loma Linda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,100 participants |
| Start Date | 2024-06-03 |
| Est. Completion | 2026-11 |
| Phase | Phase 3 |
What NCT06363877 shows while recruiting
NCT06363877 is an interventional study that assigns participants to a tested intervention. Its 1,100 participants enrollment target places it among the larger protocols in the corpus, above the 524-participant average among 25 other Surgical Site Infection trials with a reported enrollment target (110% higher).
The record links to 1 condition, with Surgical Site Infection appearing as the primary indexed condition, and to 2 interventions - of which Povidone-Iodine is the first listed.
NCT06363877 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT06363877 about?
NCT06363877 is a clinical study titled "Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections". This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 yea...
What is the current status of trial NCT06363877?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,100 participants. The study started on 2024-06-03. Estimated completion is 2026-11.
What conditions does trial NCT06363877 study?
This clinical trial studies the following conditions: Surgical Site Infection.
What interventions are being tested in trial NCT06363877?
The interventions under investigation include: Povidone-Iodine (DRUG), Normal Saline (DRUG).
Who is sponsoring clinical trial NCT06363877?
This trial is sponsored by Loma Linda University, which has 237 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06363877 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Surgical Site Infection
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06363877's enrollment target sits among peer trials
1,100 5th of 25 higher than 21 of 25 other Surgical Site Infection trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Surgical Site Infection trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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