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ClinicalTrials.gov 3 recruiting now official registry

Non-alcoholic Steatohepatitis clinical trials

3 of 13 indexed Non-alcoholic Steatohepatitis trials are currently recruiting.

13 US clinical trials · 3 currently recruiting

Non-alcoholic Steatohepatitis is the subject of 13 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 8 in Phase 1-2 (earlier-stage). The most active sponsor is Cirius Therapeutics, running 1 of these trials.

The research picture

Non-alcoholic Steatohepatitis has 13 registered US clinical trials, 3 of them open to new participants right now, about 23% of the total.

3
recruiting participants now
23%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
1
top sponsor: Cirius Therapeutics
Phase 11Phase 27Phase 31

Active & Recent Trials

13 total, page 1 of 1

RECRUITING NA 800 participants

The Olmsted NAFLD Epidemiology Study (TONES)

Mayo Clinic

NCT04365855

RECRUITING 150 participants

Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease

Brigham and Women's Hospital

NCT05728697

RECRUITING Phase 2 84 participants

Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT03884075

ACTIVE NOT RECRUITING Phase 3 1,205 participants

Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

Novo Nordisk A/S

NCT04822181

COMPLETED Phase 2 392 participants

A Study to Evaluate the Safety, Tolerability & Efficacy of MSDC-0602K in Patients With NASH

Cirius Therapeutics

NCT02784444

COMPLETED Phase 2 318 participants

Emricasan, a Caspase Inhibitor, for Evaluation in Subjects With Non-Alcoholic Steatohepatitis (NASH) Fibrosis

Conatus Pharmaceuticals

NCT02686762

COMPLETED 263 participants

Effect of Patient Demographics, Comorbidities, and Medications on Severity of NASH Fibrosis

Methodist Health System

NCT05357352

COMPLETED Phase 2 134 participants

A Study to Assess the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects With Non-Alcoholic Steatohepatitis

Enanta Pharmaceuticals

NCT03421431

COMPLETED Phase 1 84 participants

Safety and Tolerability Study of SHP626 in Overweight and Obese Adults

Mirum Pharmaceuticals

NCT02287779

COMPLETED Phase 2 50 participants

Ezetimibe Versus Placebo in the Treatment of Non-alcoholic Steatohepatitis

University of California, San Diego

NCT01766713

COMPLETED NA 40 participants

Mobile Health Delivered Lifestyle Intervention Program in Patients With NASH

Milton S. Hershey Medical Center

NCT04872777

COMPLETED Phase 2 21 participants

An Evaluation of the Safety and Efficacy of Nitazoxanide on Collagen Turnover in NASH Patients With Fibrosis

Pinnacle Clinical Research, P

NCT03656068

COMPLETED Phase 2 16 participants

Saroglitazar Magnesium in the Treatment of Non-Alcoholic Steatohepatitis

Zydus Therapeutics

NCT03863574

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 7
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Non-alcoholic Steatohepatitis Trial Landscape

13 indexed Non-alcoholic Steatohepatitis studies · 3 recruiting (23%).

Phase mix: 1 late (III/IV) vs 8 early (I/II).

Top sponsor: Cirius Therapeutics (1 trial), 9 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Non-alcoholic Steatohepatitis?

PlainTrial tracks 13 US clinical trials for Non-alcoholic Steatohepatitis, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Non-alcoholic Steatohepatitis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.