Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Hot Flashes: early-phase trial registry
7 of 27 indexed Hot Flashes trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #598 of 28,707 conditions by registered trial count.
27 US clinical trials · 7 currently recruiting · #598 of 28,707 conditions by registered trial count
Hot Flashes: 27 US clinical trials tracked, 7 recruiting.
Hot Flashes is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Mayo Clinic, running 3 of these trials.
Enrollment posture brief
Registry condition hot-flashes
OPEN 7 | RECR 26% | LATE 2 | EARLY 6 | RANK #598 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Coronary Artery Disease (26% recruiting · 220 trials)
Hot Flashes lists 7 open slots (26% of 27 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Hot Flashes on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Hot Flashes is recruiting below its size-band peers.
7 of 27 indexed trials (25.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Hot Flashes trials is spread across many organizations.
Mayo Clinic accounts for 3 of 27 trials (11.1%). 21 distinct sponsors appear on at least one study for this condition label.
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Typical Hot Flashes enrolment sits around 110 participants.
Median target enrolment is 110 among the 24 trials that report a genuine target (sentinel values excluded). 11 of those (45.8%) plan for fewer than 100 participants.
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Hot Flashes research is mostly interventional.
24 interventional and 3 observational studies make up this index (88.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
27 total, page 1 of 1
JDS-HF3.0 Supplementation on Menopause Related Quality of Life Outcomes in Postmenopausal Women
Bonafide Health
NCT07238478
Hot Flashes and Neurovascular Function in Women
Mayo Clinic
NCT05193968
Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients
University of Arkansas
NCT01530373
The Cardiovascular Impact of Hot Flushes
University of Minnesota
NCT05251324
Efficacy and Safety of Shatavari for Treatment of Menopausal Symptoms in Women: A Randomized, Double-blind, Three-arm, Parallel, Placebo-controlled Study
SF Research Institute
NCT06716554
Improving Sympathetic Activity, Hot Flashes, and Sleep in Midlife Women Using Inspiratory Muscle Strength Training
Mayo Clinic
NCT06743269
Men With Prostate Cancer: Optimizing Wellness by Enhanced Relief From Hot Flashes With Acupuncture
Inova Health Care Services
NCT07335224
A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats
Astellas Pharma Global Development
NCT06049797
24-Week Efficacy & Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms
Noven Therapeutics
NCT01101841
MsFLASH-02: Interventions for Relief of Menopausal Symptoms: A 3-by-2 Factorial Design Examining Yoga, Exercise, and Omega-3 Supplementation
Fred Hutchinson Cancer Center
NCT01178892
Breathe for Hot Flashes Randomized Controlled Trial
Indiana University
NCT00819182
Menopausal Symptoms in Women With Breast Cancer or At High Risk of Breast Cancer Treated on Another Clinical Trial
Case Comprehensive Cancer Center
NCT00666913
Caria: Digital Intervention for Menopause Symptom
University of Illinois at Chicago
NCT04882982
Use of Black Cohosh and Red Clover for the Relief of Menopausal Symptoms
National Center for Complementary and Integrative Health (NCCIH)
NCT00066144
Soy Protein Supplement In Treating Hot Flashes in Postmenopausal Women Receiving Tamoxifen for Breast Disease
Alliance for Clinical Trials in Oncology
NCT00031720
Herbal Dietary Supplementation on Vasomotor Symptoms in Menopausal Women
Bonafide Health
NCT07408115
Eight-Week Efficacy & Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms Associated With Menopause
Noven Therapeutics
NCT00786188
Research Investigation of Soy and Estrogen
University of Illinois at Chicago
NCT00997893
A Mobile App for Hot Flashes and Sleep Disturbances
Baylor University
NCT06718803
Embr Thermal Device for Hot Flash Management in Prostate Cancer
Embr Labs
NCT04892914
EMBr Wave for the Reduction of Hot Flashes in Women With a History of Breast Cancer
Ohio State University Comprehensive Cancer Center
NCT05086705
Pilot Study of Stellate Ganglion Injection to Provide Relief From Hot Flushes
Northwestern University
NCT00992914
Reducing the Experience of Menopausal Symptoms Through Temperature
Wake Forest University Health Sciences
NCT03937466
Skin Conduction Device for Measuring Hot Flashes in Postmenopausal Women With Hot Flashes
Mayo Clinic
NCT00427622
Gabapentin For the Control of Hot Flashes in Women With Breast Cancer
Gary Morrow
NCT00022074
Effects of Black Cohosh on Menopausal Hot Flashes
National Center for Complementary and Integrative Health (NCCIH)
NCT00010712
Cyproterone Acetate in Treating Hot Flashes Following Surgical or Chemical Castration for Prostate Cancer
Barr Laboratories
NCT00005623
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 2 | 6 |
| Phase 3 | 2 |
Top Sponsors
Named interventions
Most-linked intervention names on Hot Flashes records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Hot Flashes trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Hot Flashes page
27 registered trials, 7 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 7 Hot Flashes trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Mayo Clinic sponsors the most Hot Flashes trials on record, review their full trial history before evaluating a specific study. See Mayo Clinic's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Hot Flashes condition card totals 27 registered trials; most-linked intervention Brisdelle (paroxetine mesylate); top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.