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NCT07685028 · ClinicalTrials.gov registry record · NA
LEGACY: Lung Cancer Screening in Individuals With a Lung Cancer Family History-Protocol A
A NA study, sponsored by Massachusetts General Hospital.
- Not yet
- Registry status
- NA
- Development phase
- 250
- Enrollment target
NCT07685028: Clinical Trial NA study, sponsored by Massachusetts General Hospital.
NCT07685028 is a NA study that has not yet begun recruiting, run by Massachusetts General Hospital. The registered enrollment target is 250 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (82% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07685028, a NA study, has not yet begun recruiting, sponsored by Massachusetts General Hospital.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 250 participants
- Enrollment target
Study Summary
This research is being done to determine if an image-based deep learning model (Sybil) can accurately predict the likelihood of future lung cancer based on chest computed tomography (CT) imaging from individuals.
Primary Outcome
All subjects will be followed for lung cancer diagnosis scan for up to 5 years following the baseline scan. Sybil's performance in predicting future lung cancer diagnoses across the study population will be calculated using the area under the receiver operating curve (AUROC), which is a measure of a risk prediction model's ability to discriminate between cases and controls. Sybil's output corresponds to the cumulative annual risk of lung cancer for up to 6 years following a given scan.
Interventions
- DIAGNOSTIC_TEST CT scan
- OTHER Sybil
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2026-10-06 |
| Est. Completion | 2035-12-31 |
| Phase | NA |
What is known before NCT07685028 opens enrollment
NCT07685028 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (82% lower).
The record links to 0 conditions, and to 2 interventions - of which CT scan is the first listed.
NCT07685028 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07685028 about?
NCT07685028 is a clinical study titled "LEGACY: Lung Cancer Screening in Individuals With a Lung Cancer Family History-Protocol A". This research is being done to determine if an image-based deep learning model (Sybil) can accurately predict the likelihood of future lung cancer based on chest computed tomography (CT) imaging from individuals.
What is the current status of trial NCT07685028?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 250 participants. The study started on 2026-10-06. Estimated completion is 2035-12-31.
What interventions are being tested in trial NCT07685028?
The interventions under investigation include: CT scan (DIAGNOSTIC_TEST), Sybil (OTHER).
Who is sponsoring clinical trial NCT07685028?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07685028's enrollment target sits among peer trials
250 410th of 2000 higher than 1,567 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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