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NCT07680127 · ClinicalTrials.gov registry record · NA
TENS of Auricular Vagal Nerve for Radiation Necrosis
A NA study, sponsored by Virginia Commonwealth University.
- Not yet
- Registry status
- NA
- Development phase
- 40
- Enrollment target
NCT07680127: Clinical Trial NA study, sponsored by Virginia Commonwealth University.
NCT07680127 is a NA study that has not yet begun recruiting, run by Virginia Commonwealth University. The registered enrollment target is 40 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07680127, a NA study, has not yet begun recruiting, sponsored by Virginia Commonwealth University.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
Study Summary
This is a multi-center, randomized, blinded trial evaluating the effect of transcutaneous auricular vagal nerve stimulator (taVNS) on radiation necrosis-related cerebral edema. In this study, consenting and eligible patients will be assigned to one of two arms: treatment (Arm 1) or sham (Arm 2). Patients in both arms will have imaging performed and tissue and blood collected for assessment of changes in area of contrast enhancement and cerebral edema, inflammatory markers, and markers of blood-brain barrier permeability.
Primary Outcome
Percent change in serum inflammatory marker TNF-alpha utilizing serum inflammatory marker analysis from collected blood samples
Interventions
- DEVICE Sham
- DEVICE Transcutaneous auricular vagal nerve stimulation (taVNS)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2026-07-31 |
| Est. Completion | 2029-08-31 |
| Phase | NA |
What is known before NCT07680127 opens enrollment
NCT07680127 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Sham is the first listed.
NCT07680127 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07680127 about?
NCT07680127 is a clinical study titled "TENS of Auricular Vagal Nerve for Radiation Necrosis". This is a multi-center, randomized, blinded trial evaluating the effect of transcutaneous auricular vagal nerve stimulator (taVNS) on radiation necrosis-related cerebral edema. In this study, consenting and eligible patients will be assigned to one of two arms: treatment (Arm 1) or sham (Arm 2). Pat...
What is the current status of trial NCT07680127?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2026-07-31. Estimated completion is 2029-08-31.
What interventions are being tested in trial NCT07680127?
The interventions under investigation include: Sham (DEVICE), Transcutaneous auricular vagal nerve stimulation (taVNS) (DEVICE).
Who is sponsoring clinical trial NCT07680127?
This trial is sponsored by Virginia Commonwealth University, which has 558 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07680127's enrollment target sits among peer trials
40 1447th of 2000 higher than 465 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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