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NCT07679607 · ClinicalTrials.gov registry record · Phase 2
GCC 2545- Improving Post-Radiotherapy Respiratory Function Through Sparing Serial and Parallel Components in the Lung
A Phase 2 study, sponsored by University of Maryland, Baltimore.
- Not yet
- Registry status
- Phase 2
- Development phase
- 70
- Enrollment target
NCT07679607: Clinical Trial Phase 2 study, sponsored by University of Maryland, Baltimore.
NCT07679607 is a Phase 2 study that has not yet begun recruiting, run by University of Maryland, Baltimore. The registered enrollment target is 70 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (47% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07679607, a Phase 2 study, has not yet begun recruiting, sponsored by University of Maryland, Baltimore.
- NOT YET RECRUITING
- Registry status
- Phase 2
- Development phase
- 70 participants
- Enrollment target
Study Summary
Decreased respiratory function is a common side effect experienced by non-small cell lung cancer (NSCLC) patients who receive radiation therapy. In current clinical practice when treating cancerous lesions in the lung, it is not standard to explicitly try and avoid excessive radiation dose and therefore radiation injury to smaller airways. However, because of this patients may obtain damage to an airway segment can cause downstream regions in the lung to lose their "supply line" and, therefore, cause patients to lose the ability to exchange oxygen with the blood. The purpose of this clinical trial is to systematically compare post-treatment lung function of those who receive regular clinical radiation therapy (standard of care \[SoC\]) versus those who receive the airway-sparing radiation therapy regimen. The investigators hope to show that, by preserving airways and connected lung regions, participants will be able to retain a larger amount of their lung function, which will have a direct, positive impact on their post-treatment quality of life.
Primary Outcome
The central objective of this trial is to determine if dose-sparing of airways and connected high-functioning sub-lobar lung volumes leads to superior preservation of post-RT ventilation compared to that achieved through SOC RT
Interventions
- RADIATION SOC Radiation Treatment Planning
- RADIATION INSPIRE Radiation Treatment Planning
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2026-08 |
| Est. Completion | 2030-08 |
| Phase | Phase 2 |
What is known before NCT07679607 opens enrollment
NCT07679607 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (47% lower).
The record links to 0 conditions, and to 2 interventions - of which SOC Radiation Treatment Planning is the first listed.
NCT07679607 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07679607 about?
NCT07679607 is a clinical study titled "GCC 2545- Improving Post-Radiotherapy Respiratory Function Through Sparing Serial and Parallel Components in the Lung". Decreased respiratory function is a common side effect experienced by non-small cell lung cancer (NSCLC) patients who receive radiation therapy. In current clinical practice when treating cancerous lesions in the lung, it is not standard to explicitly try and avoid excessive radiation dose and there...
What is the current status of trial NCT07679607?
This trial is currently not yet recruiting. It is a Phase 2 study. The enrollment target is 70 participants. The study started on 2026-08. Estimated completion is 2030-08.
What interventions are being tested in trial NCT07679607?
The interventions under investigation include: SOC Radiation Treatment Planning (RADIATION), INSPIRE Radiation Treatment Planning (RADIATION).
Who is sponsoring clinical trial NCT07679607?
This trial is sponsored by University of Maryland, Baltimore, which has 560 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07679607's enrollment target sits among peer trials
70 937th of 2000 higher than 1,036 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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