Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07674264 · ClinicalTrials.gov registry record · NA
Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
A NA study, sponsored by University of Florida.
- Recruiting
- Registry status
- NA
- Development phase
- 32
- Enrollment target
NCT07674264: Recruiting NA study, sponsored by University of Florida.
NCT07674264 is a NA study that is actively recruiting participants, run by University of Florida. The registered enrollment target is 32 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07674264, a NA study, is actively recruiting participants, sponsored by University of Florida.
- RECRUITING
- Registry status
- NA
- Development phase
- 32 participants
- Enrollment target
Study Summary
Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) or hypercapnic normoxia (AIHN) improves upper airway and axial motor function in Parkinsonism, and explores biomarker correlates of intervention responsiveness.
Primary Outcome
Within-subject differences in sound pressure level (decibels) pre/post intervention and differences between intervention groups (AIHH vs. AIHN) during sustained phonation and connected speech.
Interventions
- OTHER Acute intermittent hypercapnic hypoxia (AIHH)
- OTHER Acute intermittent hypercapnic normoxia (AIHN)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2026-06-20 |
| Est. Completion | 2028-12-31 |
| Phase | NA |
What NCT07674264 shows while recruiting
NCT07674264 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 0 conditions, and to 2 interventions - of which Acute intermittent hypercapnic hypoxia (AIHH) is the first listed.
NCT07674264 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07674264 about?
NCT07674264 is a clinical study titled "Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD". Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies. This randomized pilot trial tests whether a single session of acute intermittent hypercapnic hypoxia (AIHH) or...
What is the current status of trial NCT07674264?
This trial is currently recruiting. It is a NA study. The enrollment target is 32 participants. The study started on 2026-06-20. Estimated completion is 2028-12-31.
What interventions are being tested in trial NCT07674264?
The interventions under investigation include: Acute intermittent hypercapnic hypoxia (AIHH) (OTHER), Acute intermittent hypercapnic normoxia (AIHN) (OTHER).
Who is sponsoring clinical trial NCT07674264?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07674264's enrollment target sits among peer trials
32 1578th of 2000 higher than 409 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02445781 · 32 participants · Early Phase 1
Differing Levels of Hypoglycemia
- NCT02792270 · 32 participants · NA
Caloric Restriction In Sarcoma Patients Treated With Pre-Operative RT
- NCT03068910 · 32 participants · Early Phase 1
Hyperandrogenemia and Altered Day-night LH Pulse Patterns
- NCT03208868 · 32 participants · NA
Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI