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NCT07667647 · ClinicalTrials.gov registry record · NA
MoDi Twin Placental Imaging
A NA study, sponsored by Carilion Clinic.
- Not yet
- Registry status
- NA
- Development phase
- 10
- Enrollment target
NCT07667647 is a NA study that has not yet begun recruiting, run by Carilion Clinic. The registered enrollment target is 10 participants.
The verdict
NCT07667647, a NA study, has not yet begun recruiting, sponsored by Carilion Clinic.
- NOT YET RECRUITING
- Registry status
- NA
- Development phase
- 10 participants
- Enrollment target
Study Summary
Twin-twin transfusion syndrome (TTTS) can arise in monochorionic, diamniotic (MoDi), those identical twins arising from division of a single fertilized ovum at 4-8 days gestational age (GA) or monochorionic, monoamniotic (MoMo or Mono-Mono) twins, arising from division on day 8-13 GA. In monochorionic twin pregnancies sharing a single placenta often unevenly, anastomoses \[connections\] artery to artery (AA), vein to vein (VV), and artery to vein (AV) can occur. AV anastomoses usually flow unilaterally, shunting blood unevenly towards one twin and away from the other. This can lead to fluid overload and polyhydramnios along with many other pathologies in one twin while the other twin suffers from inadequate blood flow and oligohydramnios, along with secondary pathologies arising from these conditions. TTTS will affect approximately 8-10% of MoDi twins while 6% of MoMo twins will suffer with this condition. Treatment for TTTS is necessary, with the donor or 'pump' twin having around an 80% chance of death without medical intervention. The aim of this single arm, unblinded, feasibility study of the Verasonics Vantage 256 device is to leverage the devices ultrafast power Doppler imaging (uPDI) to perform microvascular mapping of the placenta in healthy, non-anomalous, 18-26 week gestational age (GA), monochorionic, diamniotic (MoDi) or monochorionic, monoamniotic (MoMo/MonoMono) pregnancies without TTTS, twin reversed arterial perfusion sequence (TRAP), or maternal vascular disease. Participants will be recruited in the Maternal Fetal Medicine department of Carilion Clinic, which specializes in high risk or complicated pregnancies. Pregnant subjects carrying monochorionic twins and scheduled for appointments at the clinic, who meet study eligibility criteria, will be approached between weeks 18 and 26 for study enrollment. Those providing informed consent will undergo a single, transabdominal ultrasound examination by a licensed ultrasonographer or obstetrician
Interventions
- DEVICE Verasonics Vantage 256 Ultrasound
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2026-07-01 |
| Est. Completion | 2029-07-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT07667647
The ClinicalTrials.gov registry entry for NCT07667647 describes a study currently listed as not yet recruiting, categorized as NA. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Carilion Clinic, which has 45 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Verasonics Vantage 256 Ultrasound is the first listed.
NCT07667647 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT07667647 about?
NCT07667647 is a clinical study titled "MoDi Twin Placental Imaging". Twin-twin transfusion syndrome (TTTS) can arise in monochorionic, diamniotic (MoDi), those identical twins arising from division of a single fertilized ovum at 4-8 days gestational age (GA) or monochorionic, monoamniotic (MoMo or Mono-Mono) twins, arising from division on day 8-13 GA. In monochorio...
What is the current status of trial NCT07667647?
This trial is currently not yet recruiting. It is a NA study. The enrollment target is 10 participants. The study started on 2026-07-01. Estimated completion is 2029-07-01.
What interventions are being tested in trial NCT07667647?
The interventions under investigation include: Verasonics Vantage 256 Ultrasound (DEVICE).
Who is sponsoring clinical trial NCT07667647?
This trial is sponsored by Carilion Clinic, which has 45 total clinical trials registered on ClinicalTrials.gov.
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